祛风化痰通络方联合督脉三针对脑梗死恢复期患者炎性因子、血管内皮功能及氧化应激的影响

目的 探讨祛风化痰通络方联合督脉三针对脑梗死恢复期患者炎性因子、血管内皮功能及氧化应激的影响。方法 选取2019年1月至2020年12月北京中医药大学孙思邈医院收治的脑梗死恢复期患者78例,按随机数表法分为研究组与对照组,各39例。患者给予常规西医治疗的基础上,对照组行督脉三针治疗,研究组行祛风化痰通络方联合督脉三针治疗,持续治疗12周。比较两组美国国立卫生研究院卒中量表（the National Institutes of Health Stroke Scale,NIHSS）评分、中医证候评分、炎性因子白介素-6（interleukin-6,IL-6）、肿瘤坏死因子α（tumor necrosis fctor-alpha,TNF-α）、超敏C反应蛋白（high sensitivity C-reactive protein,hs-CRP）]、血管内皮功能因子一氧化氮（nitric oxide,NO）、血管性血友病因子（von Willebrand factor,vWF）、内皮素-1（endothelin-1,ET-1）]与氧化应激因子超氧化物歧化酶（superoxide dismutase,SOD）、谷胱甘肽过氧化物酶（Glutathione Peroxidose,GSH-Px）、丙二醛（malondialdehyde,MDA）]的水平。结果 治疗过程中研究组脱落1例,对照组脱落2例,最终研究组38例,对照组37例纳入研究。治疗后,两组NIHSS、中医证候评分、IL-6、TNF-α、hs-CRP、vWF、ET-1与MDA较治疗前降低,且研究组低于对照组,差异均有统计学意义（P<0.05）;NO、SOD与GSH-Px水平较治疗前升高,且研究组水平高于对照组,差异均有统计学意义（P<0.05）。结论 祛风化痰通络方联合督脉三针治疗恢复期脑梗死患者可减轻神经功能缺损程度,改善中医证候,并能够抑制炎性反应、调节氧化应激、改善血管内皮功能。

Effects of Qufeng Huatan Tongluo Recipe combined with Du meridian three-needle acupuncture on inflammatory factors,vascular endothelial function and oxidative stress in patients with cerebral infarction

Objective To explore the effect of Qufeng Huatan Tongluo Recipe and Du meridian three-needle acupuncture on inflammatory factors, vascular endothelial function and oxidative stress in patients with cerebral infarction. Methods A total of 78 patients in the convalescent period of cerebral infarction admitted to Sun Simiao Hospital of Beijing University of Traditional Chinese Medicine from January 2019 to December 2020 were divided into study group and control group according to the random number table method, with 39 cases in each. The patients were all given conventional western medicine treatment. On the basis of these, the control group was given the Du meridian three-needle acupuncture, and the study group was treated with Qufeng Huatan Tongluo Recipe combined with the Du meridian three-needle acupuncture for 12 weeks. The National Institutes of Health Stroke Scale （NIHSS） score, traditional Chinese medicine （TCM） syndrome score, inflammatory factors interleukin-6（IL-6）, tumor necrosis factor α （TNF-α）, high sensitivity C-reactive protein （hs-CRP）], vascular endothelial function nitric oxide （NO）, von Willebrand factor （vWF）, endothelin-1 （ET-1）], and oxidative stress factors superoxide dismutase （SOD）, glutathione peroxidase （GSH-Px）, malondialdehyde （MDA）] were compared between the two groups. Results During the treatment, 1 case in the study group and 2 cases in the control group were lost, and finally 38 cases in the study group and 37 cases in the control group were included in the study. After treatment, NIHSS, TCM syndrome scores, IL-6, TNF-α, hs-CRP, vWF, ET-1 and MDA in the two groups were lower than those before treatment, and the study group was lower than the control group, with statistical significance （P<0.05）. The levels of NO, SOD and GSH-Px were higher than those before treatment, and the levels in the study group were higher than those in the control group, and the differences were statistically significant （P<0.05）. Conclusion Qufeng Huatan Tongluo Recipe combined with Du meridian three-needle acupuncture in the treatment of convalescent cerebral infarction can reduce the degree of neurological deficit, improve TCM syndromes, inhibit inflammation, regulate oxidative stress, and improve vascular endothelial function.