基于扩散磁共振的脑组织微结构成像研究综述

微结构成像是为了改善传统扩散磁共振成像的一些缺点而发展的一种新技术.微结构成像范式旨在建立组织结构特性与体素级磁共振信号相联系的模型,以此来估计并绘制微结构属性.目前该技术正在实现从实验室研究到临床应用研究的转变.首先介绍扩散磁共振成像并分析传统技术存在的主要问题,然后阐述微结构成像原理;随后,对受阻与受限制复合扩散模...

A Review of Brain Tissue Microstructural Imaging Based on Diffusion Magnetic Resonance

Microstructure imaging is a new technology developed to improve some of the shortcomings of traditional diffusion magnetic resonance imaging. The microstructure imaging paradigm aims to estimate and map microscopic properties of tissue using a model that links these properties to the voxel scale MR signal. It is currently undergoing a transition from laboratory research to clinical applications. In this article, we first introduced the diffusion magnetic resonance imaging technology, analyzed the main problems existing and explained the principle of microstructure imaging. In the following parts, the research status of multi-compartment models was reviewed such as CHARMED and NODDI, including model composition, model optimization and clinical application. The research progress of deep learning algorithm applied to microstructure imaging was reviewed as well. At last, the development trend of microstructure imaging technology was prospected.