| 艰难梭菌感染治疗方法 |
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| 引用本文： | 王暄,杨靖,赵建宏.艰难梭菌感染治疗方法[J].分子诊断与治疗杂志,2013(6):422-426. |
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| 作者姓名： | 王暄 杨靖 赵建宏 |
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| 作者单位： | [1]石家庄市第一医院检验科,河北石家庄050051 [2]河北省临床检验中心,河北石家庄050000 [3]河北医科大学第二医院检验科,河北石家庄050000 |
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| 基金项目： | 河北省自然科学基金（2013206450）；河北省科技厅基础条件平台建设项目 |
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| 摘 要： | 艰难梭菌为革兰阳性厌氧芽孢杆菌，可引起艰难梭菌相关性腹泻（CDAD），导致一系列的肠道感染症状。CDAD的发病率在全球范围内不断提高，尤其是高产毒株在北美地区造成了医院内的暴发流行，引起了世界范围的关注。近年来，国外相继出现了耐甲硝唑和万古霉素的艰难梭菌的报道，传统的治疗方法面临严重挑战，一些新的治疗方法应运而生。本文将对CDAD的治疗方法及其进展做一简要综述。
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| 关 键 词： | 艰难梭菌 感染 腹泻 治疗 |
The new developments in treatment of Clostridiumdififcile infection |
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| WANG Xuan,YANG Jing,ZHAO Jianhong.The new developments in treatment of Clostridiumdififcile infection[J].Journal of Molecular Diagnosis and Therapy,2013(6):422-426. |
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| Authors: | WANG Xuan YANG Jing ZHAO Jianhong |
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| Institution: | 1.Department of Clinical Laboratory Science, First Hospital of Shijiazhuang, Hebei, Shijiazhuang 050051, China; 2.Departlnent of Clinical Laboratory Science, Second Hospital of Hebei Medical University, Hebei, Shijiazhuang 050000, China; 3.Hebei Provincial Centre for Clinical Laboratory, Hebei, Shijiazhuang 050000, China) |
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| Abstract: | Clostridium difficile, a gram-positive anaerobic spore-forming bacillus, commonly caused Clostridium difficile associated diarrhea （CDAD）, and leaded to a series of intestinal infection symptoms. The globally increasing incidence of CDAD, especially the outbreak of nosocomial infection caused by the hypervirulent strain in North America, arouse worldwide attention. In recent years, some reports for metronidazole and vancomycin-resistance in Clostridiumdifficile have been appeared. So the traditional treatment methods were facing serious challenge, meanwhile, some new therapeutic approaches had been emerged. This review would summarize the latest development on treatment options of Clostridiumdifficile. |
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| Keywords: | Clostridiumdifficile Infection Diarrhea Treatment |
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