| 神经生长因子对大鼠坐骨神经损伤的修复作用 |
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| 引用本文： | 邵阳,伍亚民,陈恒胜,李民,廖维宏. 神经生长因子对大鼠坐骨神经损伤的修复作用[J]. 中国临床药学杂志, 2001, 10(3): 157-159 |
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| 作者姓名： | 邵阳 伍亚民 陈恒胜 李民 廖维宏 |
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| 作者单位： | 中国人民解放军第三军医大学大坪医院野战外科研究所 |
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| 基金项目： | 国家重点基础研究发展规划项目资助!NO.G19990 5 42 0 6 |
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| 摘 要： | 目的：观察大鼠坐骨神经横断挫伤后，外源性神经生长因子（NGF）对大鼠周围神经损伤的修复作用。方法：采用大鼠坐骨神经横断致伤方法，实验分为：假手术组、生理盐水对照组、NGF组，每组10只，观察时间为2wk。结果：术后2wk,NGF组的体感诱发电位（SEP）、运动诱发电位（MEP）与生理盐水对照组相比，潜伏期明显缩短（P＜0．05）。经Tarlov评分，NGF组有70％可恢复到4－5分，而生理盐水对照组只有20％恢复到4－5分。结论：NGF对周围神经损伤后有促进神经传导和损伤修复的作用。
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| 关 键 词： | 神经生长因子 周围神经损伤 诱发电位 NGF 实验药理学 |
| 文章编号： | 1007-4406(2001)03-0157-03 |
Effect of nerve growth factor on repair of sciatic nerve injury in rats |
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| Shao Yang,Wu Yamin,Chen Hengsheng,Li Min,Liao Weihong. Effect of nerve growth factor on repair of sciatic nerve injury in rats[J]. Chinese Journal of Clinical Pharmacy, 2001, 10(3): 157-159 |
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| Authors: | Shao Yang Wu Yamin Chen Hengsheng Li Min Liao Weihong |
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| Abstract: | AIM: To investigate the therapeutic effect of nerve growth factor (NGF) following sciatic nerve section injury. METHODS: The sciatic nerves of rats were injured by section with shaver, which were divided into 3 groups: sham operation group, control group of normal saline (NS), and the group of NGF. Every group consisted of 10 rats. The time points of observation was at 2 wk after operation. RESULTS: The latency of sensory evoked potential (SEP) in the treated group at 2 wk after operation was shorter than that in NS group ( P <0 05). The latency of both N 1 and P 1 of motor evoked potential (MEP) in therapeutic group was shorter than that in NS group ( P <0 05-0 01). CONCLUSION: NGF can improve the conductive function of injured peripheral nerve. |
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| Keywords: | nerve growth factor peripheral nerve injury motor evoked potential |
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