岩舒注射液与香菇多糖合用治疗晚期消化道癌的临床观察

目的：观察岩舒注射液与香菇多糖合用治疗晚期消化道癌的临床疗效。方法：78例老年晚期消化道癌患者随机分为实验组（38例）和对照组（40例）,实验组患者每天给予岩舒注射液15mL＋5%葡萄糖氯化钠注射液250mL静脉滴注,香菇多糖1mg加入5%葡萄糖注射液250mL中静脉滴注,每天1次,连用14天为1个周期,休息7天后重复,共用2-3个周期;对照组患者每天只给予香菇多糖治疗。结果：实验组有效率高于对照组（31.6% vs 10.0%,χ^2=5.565,P=0.018）,差异有显著性。两组生存质量与治疗前比较明显提高,差异有统计学意义（P=0.002 6;0.0300）,实验组治疗后生存质量较对照组为高,差异无统计学意义（P〉0.05）;实验组与对照组中位生存期分别为10.6月和7.8月;两组不良反应较轻。结论：岩舒注射液与香菇多糖合用治疗晚期消化道癌具有一定的临床疗效,能改善患者的生存质量,延长生存期,无明显不良反应。

Clinical Evaluation on Yanshu Injection plus Lentinan in the Treatment of Advanced Digestive Tract Cancer

OBJECTIVE： To observe the clinical efficacy of Yanshu injection plus lentinan in the treatment of advanced digestive tract cancer. METHODS： A total of 78 elderly patients with advanced digestive tract cancer were enrolled： 38 （experimental group）were randomly assigned to receive Yanshu injection 15 mL infused in 5 % GNS 250 mL by i. v drip plus 1 mg lentinan infused in 250 mL Glucose by iv. drip q.d for 14days （1 cycle）, and altogether 2 - 3 cycles were needed with an interval of 7days; 40 （control group）to receive lentinan alone. RESULTS： The overall effective rate in the Experimental group was significantly higher than that in the control group （31.6% vs 10.0%, Χ^2 = 5.565, P = 0.018）, showing significant differences. The quality of life in both groups improved significantly, showing significant difference as compared before treatment （ P = 0. 002 6 ; 0. 030 0）. The quality of life in experimental group after treatment was higher than in control group, but the difference not statistically significant （ P 〉 0.05 ） ; The median survival time was 10.6 months in experimental group versus 7.8 months in control group; The side effects in both groups were slight. CONCLUSION： Yanshu injection plus lentinan can improve life quality and prolong survival time yet without obvious adverse drug reactions in patients with advanced cancer of the digestive tract.