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岩舒注射液与香菇多糖合用治疗晚期消化道癌的临床观察
引用本文:林清,钟智,谢忠,马晓鹏. 岩舒注射液与香菇多糖合用治疗晚期消化道癌的临床观察[J]. 中国医院用药评价与分析, 2008, 8(7): 531-532
作者姓名:林清  钟智  谢忠  马晓鹏
作者单位:1. 广东医学院附属医院药剂科,湛江市,524001
2. 广东医学院附属医院肿瘤科,湛江市,524001
摘    要:目的:观察岩舒注射液与香菇多糖合用治疗晚期消化道癌的临床疗效。方法:78例老年晚期消化道癌患者随机分为实验组(38例)和对照组(40例),实验组患者每天给予岩舒注射液15mL+5%葡萄糖氯化钠注射液250mL静脉滴注,香菇多糖1mg加入5%葡萄糖注射液250mL中静脉滴注,每天1次,连用14天为1个周期,休息7天后重复,共用2-3个周期;对照组患者每天只给予香菇多糖治疗。结果:实验组有效率高于对照组(31.6% vs 10.0%,χ^2=5.565,P=0.018),差异有显著性。两组生存质量与治疗前比较明显提高,差异有统计学意义(P=0.002 6;0.0300),实验组治疗后生存质量较对照组为高,差异无统计学意义(P〉0.05);实验组与对照组中位生存期分别为10.6月和7.8月;两组不良反应较轻。结论:岩舒注射液与香菇多糖合用治疗晚期消化道癌具有一定的临床疗效,能改善患者的生存质量,延长生存期,无明显不良反应。

关 键 词:晚期消化道癌  岩舒  香菇多糖

Clinical Evaluation on Yanshu Injection plus Lentinan in the Treatment of Advanced Digestive Tract Cancer
Affiliation:LIN Qing , ZHONG Zhi , XIE Zhong , MA Xiao-li ( 1. Dept. of Pharmacy, The Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China; 2. Dept. of Radiation Oncology, The Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China)
Abstract:OBJECTIVE: To observe the clinical efficacy of Yanshu injection plus lentinan in the treatment of advanced digestive tract cancer. METHODS: A total of 78 elderly patients with advanced digestive tract cancer were enrolled: 38 (experimental group)were randomly assigned to receive Yanshu injection 15 mL infused in 5 % GNS 250 mL by i. v drip plus 1 mg lentinan infused in 250 mL Glucose by iv. drip q.d for 14days (1 cycle), and altogether 2 - 3 cycles were needed with an interval of 7days; 40 (control group)to receive lentinan alone. RESULTS: The overall effective rate in the Experimental group was significantly higher than that in the control group (31.6% vs 10.0%, Χ^2 = 5.565, P = 0.018), showing significant differences. The quality of life in both groups improved significantly, showing significant difference as compared before treatment ( P = 0. 002 6 ; 0. 030 0). The quality of life in experimental group after treatment was higher than in control group, but the difference not statistically significant ( P 〉 0.05 ) ; The median survival time was 10.6 months in experimental group versus 7.8 months in control group; The side effects in both groups were slight. CONCLUSION: Yanshu injection plus lentinan can improve life quality and prolong survival time yet without obvious adverse drug reactions in patients with advanced cancer of the digestive tract.
Keywords:Advanced cancer of digestive tract  Yanshu  Lentinan
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