变态反应与烟雾病关系的实验研究

目的：探讨免疫复合物与烟雾病之间的关系。方法：用颈局部注射马血清方法建立烟雾病的实验动物模型。结果：颈动脉受免疫复合物损伤后，内弹力层变性、迂曲、断裂、中膜平滑肌间力纤维断裂处向内腔伸入增生，致管腔狭窄或闭塞，脑组织长期缺血，小血管及毛细血管代偿性增生形成异网。结论：变化反应性免疫复合物对颈动脉的损伤可能是引起烟雾病的原因。

An Experimental Study on the Pathogenic Role of Immune Complex to Moyamoya Disease

Objective To explore the relation between the immunologicalcomplex and moyamoya disease. Methods the experimental rabbit model of moyamoya disease was established with normal horse serum injected into the neck regions on both sides of the common carotid arteries.Results The carotid arteries were injured with the immunological complexes,the elastic fibrous laminas of the carotid arteries became degenerated、tortuous and cracked, the smooth muscles cell grew toward the lumen along the regions of elastic fibrous laminas cracks ,leading to carotid arterial stenosis or occulusion. Eventually, small arteries and capillaries grew with compensation and formed the pathology of moyamoya disease after a long perid of chronic ischemia. Conclusions The experimental results indicated that the immunopathological injuries of the arteries at the neck areas might be pathogenetic factor of moyamoya disease.