Effect of diquertin on platelet content of cyclic nucleotides |
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| Authors: | A. A. Kubatiev Z. T. Yadigarova I. A. Rud'ko V. A. Bykov N. A. Tyukavkina |
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| Affiliation: | (1) Department of General Pathology and Pathophysiology, Russian Academy of Postgraduate Education, Moscow |
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| Abstract: | The effects of diquertin on the content of cyclic nucleotides in human platelets was studied. Diquertin in a concentration of 5 mM increased the content of cAMP and cGMP in native and thrombin-activated platelets probably due to inhibition of phosphodiesterase. Increasing the concentration of diquertin above 5 mM did not potentiate this effect. The antiaggregation effect of diquertin was probably associated with the increase in platelet levels of cyclic nucleotides. Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny,Vol. 128, No. 9, pp. 267–269, September, 1999 |
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| Keywords: | flavonoids diquertin platelet cyclic nucleotides |
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