64层CT灌注在胰腺癌诊断中的价值

目的：探讨胰腺CT灌注成像的可行性，研究正常胰腺与胰腺癌的64-CT灌注参数特征。方法：采用64层螺旋CT对24例正常胰腺志愿者和35例胰腺癌患者进行胰腺灌注扫描，测量并比较正常胰腺和胰腺癌的血流量（BF）、血容量（BV）、峰值（PE）、达峰时间（TTP）和渗透性（P值）等灌注参数。结果：胰腺癌组的BF、BV、PE小于正常组，TTP、P大于正常组，差异有显著性。癌组织BF、BV、PE明显小于残余正常胰腺组织，TTP、P大于残余正常胰腺组织，差异有显著性。第2、3、4期P值高于第1期胰腺癌，差异有统计学意义。结论：胰腺CT灌注成像能够在一定程度上反映出胰腺及胰腺癌的血流灌注特点，对胰腺癌的诊断有提示意义。胰腺癌组织和残余正常胰腺组织灌注参数对比在临床上对胰腺癌的诊断有价值。

Perfusion imaging with 64-slice CT in diagnosis of pancreatic cancer

Objective: To assess the feasibility of 64-CT perfusion of normal pancreas and compare the perfusion parameters between normal pancreas and pancreatic cancer. Methods: Twenty-four healthy subjects and 35 patients with pancreatic cancer underwent CT perfusion on a 64-slice CT of Siemens. The raw data was calculated with Siemens software and the perfusion characteristic parameters(including BF, BV, PE, TTP, P) were compared. Results: Pancreatic cancer showed higher P and lower BF, BV and PE compared with those of normal pancreas. Cancer tissue showed lower BF, BV and PE, but higher TTP and P compared with normal tissue in the same patient(P<0.05). Pancreatic cancer type 2, 3, 4 showed higher P compared with type 1(P<0.05). Conclusion: CT perfusion is a feasible technique to assess pancreatic blood perfusion. Comparation of perfusion parameters of normal tissue and pancreatic cancer tissue of the same patient can be a good option in the diagnosis of pancreatic cancer. Permeability can assess the degree of blood vessels destruction.