| 奥美沙坦酯片在健康人体内的药动学 |
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| 引用本文： | 杨武云,李珍,唐世新,计一平,康新,胡晋红.奥美沙坦酯片在健康人体内的药动学[J].药学服务与研究,2009,9(5):367-369. |
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| 作者姓名： | 杨武云 李珍 唐世新 计一平 康新 胡晋红 |
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| 作者单位： | 第二军医大学长海医院药学部,上海,200433 |
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| 摘 要： | 目的：研究奥美沙坦酯片在健康人体内的药动学。方法：10名健康男性志愿者单剂量口服20 mg奥美沙坦酯片,采用HPLC荧光检测法测定血浆中奥美沙坦浓度,并计算药动学参数。结果：健康志愿者单剂量口服奥美沙坦酯片后的主要药动学参数为：cmax（526.88±75.74）ng/mL,tmax（2.05±0.37）h,t1/2（12.68±2.37）h,MRT（13.86±3.51）h,Cl/F（4.66±0.67）L/h,AUC0-48（3 990.43±679.47）ng.h.mL^-1,AUC0-∞（4 367.95±602.53）ng.h.mL^-1。结论：健康志愿者口服奥美沙坦酯片后吸收迅速,主要药动学参数与国内外文献报道值基本一致。
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| 关 键 词： | 奥美沙坦 色谱法 高压液相 药代动力学 |
Pharmacokinetics of olmesartan medoxomil tablets in healthy volunteers |
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| YANG Wu-yun,LI Zhen,TANG Shi-xin,JI Yi-ping,KANG Xin,HU Jin-hong.Pharmacokinetics of olmesartan medoxomil tablets in healthy volunteers[J].Pharmaceutical Care and Research,2009,9(5):367-369. |
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| Authors: | YANG Wu-yun LI Zhen TANG Shi-xin JI Yi-ping KANG Xin HU Jin-hong |
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| Institution: | ( Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China) |
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| Abstract: | Objective：To study the pharmacokinetics of olmesartan medoxomil tablets in Chinese healthy volunteers.Methods：Ten healthy male volunteers were given a single oral dose of 20 mg olmesartan medoxomil tablet.Plasma concentrations of olmesartan were determined by HPLC method with fluorescence detection.Results：The main pharmacokinetic parameters were as follows： cmax（526.88±75.74） ng/mL,tmax（2.05±0.37） h,t1/2（12.68±2.37） h,MRT（13.86±3.51） h,Cl/F（4.66±0.67） L/h,AUC0-48（3 990.43±679.47） ng·h·mL^-1 and AUC0-∞（4 367.95±602.53）ng·h·mL^-1 .Conclusion：Olmesartan medoxomil can be rapidly absorbed after oral administration. The main pharmacokinetic parameters are consistent with the values reported in literature. |
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| Keywords: | olmesartan chromatography high pressure liquid pharmacokinetics |
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