不同促渗剂对芍药苷凝胶体外透皮吸收的影响

目的] 研究芍药苷（PF）的理化性质及考察薄荷油、桉叶油、油酸、氮酮4种促渗剂对PF凝胶中PF体外透皮吸收的影响，筛选出最佳的促渗剂。方法] 采用摇瓶法测定PF的表观溶解度及油水分配系数；采用改良Franz扩散池，以大鼠离体皮肤为模型，通过高效液相色谱（HPLC）法测定药物浓度，拟合PF透皮吸收的累积透过量和透过速率。结果] 7%薄荷油、5%薄荷油、4%桉叶油及3%油酸均可以不同程度地促进PF凝胶中PF透皮吸收，其促渗效果顺序为7%薄荷油＞5%薄荷油＞4%桉叶油＞3%油酸。结论] 7%薄荷油为PF凝胶的最佳促渗剂。

Effect of different penetration enhancers on percutaneous absorption of paeoniflorin in vitro

Objective] To study the physical and chemical properties of paeoniflorin(PF) and the effects of peppermint oil,eucalyptus oil,oleic acid,azone and four penetration enhancers on the percutaneous absorption of PF in PF gel in vitro. Methods] The apparent solubility and oil-water partition coefficient of PF were determined by shake-flask method,and the concentration of PE in rat skin was determined by HPLC,accumulation of PF and its permeation rate through rat skin. Results] The 7% peppermint oil,5% peppermint oil,4% eucalyptus oil and 3% oleic acid could improve the transdermal absorption of PF gel,the order of enhancing permeability was 7% peppermint oil >5% peppermint oil >4% eucalyptus oil >3% oleic acid. Conclusion] The 7% peppermint oil was the best penetration enhancer for PF gel.