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Intravenous vitamin C therapy in adult patients with sepsis: A rapid practice guideline
Authors:Annika Reintam Blaser  Waleed Alhazzani  Emilie Belley-Cote  Morten Hylander Møller  Neill K. J. Adhikari  Lisa Burry  Craig M. Coopersmith  Zainab Al Duhailib  Tomoko Fujii  Anders Granholm  Jan Gunst  Naomi Hammond  Lu Ke  Francois Lamontagne  Cecilia Loudet  Matt Morgan  Marlies Ostermann  Matti Reinikainen  Ricardo Rosenfeld  Claudia Spies  Simon Oczkowski
Affiliation:1. Department of Anaesthesiology and Intensive Care, University of Tartu, Tartu, Estonia;2. Department of Medicine, McMaster University, Hamilton, Canada

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada

Department of Critical Care, College of Medicine, King Saud University, Riyadh, Saudi Arabia

Research Institute of St. Joseph's Healthcare Hamilton, Hamilton, Canada

GUIDE Group, Hamilton, Canada;3. Department of Medicine, McMaster University, Hamilton, Canada

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada

GUIDE Group, Hamilton, Canada

Population Health Research Institute, Hamilton, Canada;4. GUIDE Group, Hamilton, Canada

Department of Intensive Care, University of Copenhagen, Copenhagen, Denmark;5. Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada

Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada;6. Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada

Leslie Dan Faculty of Pharmacy, University of Toronto and Sinai Health System, Toronto, Canada;7. Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Georgia;8. GUIDE Group, Hamilton, Canada

Critical Care Medicine Department, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia;9. Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia

Intensive Care Unit, Jikei University Hospital, Tokyo, Japan;10. GUIDE Group, Hamilton, Canada;11. Laboratory of Intensive-Care Medicine, Department of Cellular and Molecular Medicine, Leuven, Belgium

Department of Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium;12. The George Institute for Global Health, UNSW Sydney, Newtown, Australia

Malcolm Fisher Department of Intensive Care, Royal North Shore Hospital, St Leonards, Australia;13. Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China

National Institute of Healthcare Data Science, Nanjing University, Nanjing, China;14. Université de Sherbrooke, Sherbrooke, Canada;15. Intensive Care Unit, Hospital Interzonal General de Agudos General San Martín de La Plata, Buenos Aires, Argentina

Department of Internal Medicine, Applied Pharmacology and Intensive Care, University of La Plata, La Plata, Argentina;16. Intensive Care Medicine Consultant, The Royal Perth Hospital, Perth, Australia;17. Department of Critical Care, King's College London, Guy's & St Thomas' Hospital, London, UK;18. University of Eastern Finland and Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland;19. Nutrition Support Team, Casa de Saude Sao Jose—Rede Santa Catarina, Rio de Janeiro, Brazil;20. Department for Anesthesiology and Intensive Care Medicine, Campus-Virchow-Klinikum and Campus Charité Mitte, Charité—Universitätsmedizin Berlin, Berlin, Germany;21. Department of Medicine, McMaster University, Hamilton, Canada

Abstract:
Keywords:ascorbic acid  guidelines  ICM-RPG  sepsis  vitamin C
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