Association between non-hypervascular hypointense nodules on gadoxetic acid-enhanced MRI and liver stiffness or hepatocellular carcinoma |
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| Affiliation: | 1. Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;2. Division of Hepatology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;3. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;4. Statistics and Data Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;5. Department of Radiology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea;1. Centre for Applied Biomedical Engineering Research (CABER), Health Research Institute (HRI), School of Engineering, Bernal Institute, University of Limerick, Lonsdale Building, Limerick, Ireland;2. Department of Radiology, University Hospital Limerick, Ireland;3. Department of Vascular Surgery, University Hospital Limerick, Ireland;1. Support Center for Advanced Neuroimaging – Institute for Diagnostic and Interventional Neuroradiology, University Hospital Inselspital and University of Bern, Bern, Switzerland;2. Department of Radiology, Division of Diagnostic and Interventional Neuroradiology, University Hospital, Basel, Switzerland;3. Institute of Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland,;4. Department of Neurosurgery, University Hospital Inselspital and University of Bern, Bern, Switzerland;1. University of Ottawa School of Medicine, 451 Smyth Rd., Ottawa, ON, K1H 8M, Canada;2. The Ottawa Hospital Research Institute Clinical Epidemiology Program, 501 Smyth Rd., Ottawa, ON, K1H 8L6, Canada;1. Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan;2. Research Park, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan;3. Department of Radiological Technology, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan;4. Department of Radiology, Toho University Medical Center Omori Hospital, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan;1. Department of Radiological Science and Radiation Therapy, IEO European Institute of Oncology, Milan, Italy;2. Department of Oncology, Università degli Studi di Milano, Milan, Italy;3. Università degli Studi di Milano, Postgraduation School in Radiodiagnostics, Milan, Italy;4. New Drugs and Early Drug Development for Innovative Therapies Division, IEO European Institute of Oncology, Milan, Italy;5. Division of Epidemiology and Biostatistics, IEO European Institute of Oncology, Milan, Italy;6. Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia and Division of Radiology, National Center of Oncological Hadrontherapy (CNAO Foundation), Italy;7. Present address: Department of Imaging, CDI Centro Diagnostico Italiano, Via Simone Saint Bon, Milan, Italy;1. Department of Radiology, Policlinico G.B. Rossi, University of Verona, Italy;2. Department of Radiology, Policlinico A. Gemelli, Catholic University, Rome, Italy |
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| Abstract: | PurposeTo assess the association between non-hypervascular hypointense nodules (NHHNs) on gadoxetic acid-enhanced magnetic resonance imaging (MRI) and liver stiffness (LS) in patients with chronic liver disease, and analyzed their progression to overt hepatocellular carcinoma (HCC).MethodsBetween August 2012 and March 2016, a total of 714 consecutive patients who had undergone transient elastography for LS measurement and gadoxetic acid-enhanced MRI were investigated. The association between the presence of NHHNs on the hepatobiliary phase and LS, and the patient’s HCC status [none, presence of treatment-naïve HCC, or a history of previous HCC treatment] was assessed. In patients with these nodules, cumulative progression rates of nodules to overt HCC were compared with rates of new HCC development in other parts of the liver.ResultsThe prevalence of NHHNs was 16.8% (120/714). The presence of these nodules was significantly associated with the log LS (Odds ratio [OR], 1.48, p = 0.002) and hepatitis B virus infection (OR, 3.14, p = 0.017), regardless of the patient’s HCC status. The two year cumulative progression rate of overt HCC from corresponding nodules and rate of progression to HCC in other parts of the liver were 34.1% and 18.3%, respectively (p = 0.071).ConclusionThe presence of NHHNs on gadoxetic acid-enhanced MRI was associated with higher LS and hepatitis B virus infection. Furthermore, these lesions frequently progressed to overt HCC. |
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| Keywords: | Non-hypervascular hypointense nodule Hepatocellular carcinoma Liver fibrosis Liver stiffness measurement Magnetic resonance imaging |
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