清热解毒类药抗细菌耐药性的研究进展

<正>抗生素被过度使用和滥用，导致细菌基因突变，通道蛋白改变对抗生素产生的耐药性越来越强，是一个全球性的问题。针对此问题，全球的科研人员正在积极寻找和研究能消除细菌耐药性的药物。我国拥有丰富的中草药资源，中草药具有悠久的使用历史和相对可靠的使用安全性。

Research Progress on Antibacterial Resistance of Traditional Chinese Medicine of Heat Clearing and Toxin Removing Class

In recent years, due to the widespread use of antibiotics, bacterial resistance to antibiotics is rapidly spreading. Over time, bacteria continue to evolve, leading to changes in mechanisms such as bacterial gene mutation and gene transfer. The phenomenon of bacterial resistance has led to a widespread decrease in the effectiveness of antibiotics. The emergence of multidrug-resistant and pan-resistant strains poses a significant challenge to the treatment of bacterial infectious diseases. This article provides an overview of the current status and mechanisms of bacterial resistance, and discusses in detail the action mechanisms and research progress of heat-clearing and detoxifying drugs (such as Scutellaria baicalensis, Lonicera japonica, Houttuynia cordata, Mentha, Forsythia suspensa, Coptis chinensis, Phellodendron amurense, Rheum, Prunella vulgaris, Forsythia suspensa, and Sophora flavescens 1], etc.) and their active components in combating bacterial resistance.