Abnormal brain function in neuromyelitis optica: A fMRI investigation of mPASAT |
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| Affiliation: | 1. Department of Radiology, Hainan General Hospital, Haikou 570311, China;2. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China;3. Department of Radiology, Keck School of Medicine, LAC + USC Medical Center, University of Southern California, 1200 North State Street, Los Angeles, CA 90033, USA;4. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China;1. Glenfield Hospital, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, United Kingdom;2. Heartlands Hospitals, Heart of England NHS foundation Trust, Bordesley Green E, Birmingham B9 5SS, United Kingdom;3. Kettering General Hospital, Treatment Centre, Rothwell Rd, Kettering NN16 8UZ, United Kingdom;4. University Hospital of North Midlands, Newcastle Rd, Stoke-on-Trent, ST4 6QG, United Kingdom;5. Glenfield Hospital, University Hospitals of Leicester, Groby Road Leicester LE3 9QP, United Kingdom;6. Breast Unit, King’s Mill Hospital, Sherwood Forest Hospitals, Sutton-in-Ashfield, Nottinghamshire, NG17 4JL;1. Support Center for Advanced Neuroimaging – Institute for Diagnostic and Interventional Neuroradiology, University Hospital Inselspital and University of Bern, Bern, Switzerland;2. Department of Radiology, Division of Diagnostic and Interventional Neuroradiology, University Hospital, Basel, Switzerland;3. Institute of Surgical Technology and Biomechanics, University of Bern, Bern, Switzerland,;4. Department of Neurosurgery, University Hospital Inselspital and University of Bern, Bern, Switzerland;1. Centre for Applied Biomedical Engineering Research (CABER), Health Research Institute (HRI), School of Engineering, Bernal Institute, University of Limerick, Lonsdale Building, Limerick, Ireland;2. Department of Radiology, University Hospital Limerick, Ireland;3. Department of Vascular Surgery, University Hospital Limerick, Ireland;1. University of Ottawa School of Medicine, 451 Smyth Rd., Ottawa, ON, K1H 8M, Canada;2. The Ottawa Hospital Research Institute Clinical Epidemiology Program, 501 Smyth Rd., Ottawa, ON, K1H 8L6, Canada;1. Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan;2. Research Park, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan;3. Department of Radiological Technology, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan;4. Department of Radiology, Toho University Medical Center Omori Hospital, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan;1. Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan;2. Department of Diagnostic Imaging and Interventional Radiology, Kyoto Katsura Hospital, 17 Yamada-Hirao, Nishikyo-ku, Kyoto 615-8256, Japan |
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| Abstract: | PurposeCognitive impairment with the Neuromyelitis Optica (NMO) patients is debated. The present study is to study patterns of brain activation in NMO patients during a pair of task-related fMRI.Materials and methodsWe studied 20 patients with NMO and 20 control subjects matched for age, gender, education and handedness. All patients with NMO met the 2006 Wingerchuk diagnostic criteria. The fMRI paradigm included an auditory attention monitoring task and a modified version of the Paced Auditory Serial Addition Task (mPASAT). Both tasks were temporally and spatially balanced, with the exception of task difficulty.ResultsIn mPASAT, Activation regions in control subjects included bilateral superior temporal gyri (BA22), left inferior frontal gyrus (BA45), bilateral inferior parietal lobule (BA7), left cingulate gyrus (BA32), left insula (BA13), and cerebellum. Activation regions in NMO patients included bilateral superior temporal gyri (BA22), left inferior frontal gyrus (BA9), right cingulate gyrus (BA32), right inferior parietal gyrus (BA40), left insula (BA13) and cerebellum. Some dispersed cognition related regions are greater in the patients.ConclusionsThe present study showed altered cerebral activation during mPASAT in patients with NMO relative to healthy controls. These results are speculated to provide further evidence for brain plasticity in patients with NMO. |
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| Keywords: | Neuromyelitis optica Cognition fMRI Brain plasticity |
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