High intensity focused ultrasound treatment of adenomyosis: The relationship between the features of magnetic resonance imaging on T2 weighted images and the therapeutic efficacy |
| |
| Institution: | 1. State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Haifu Hospital, College of Biomedical Engineering, Chongqing Medical University, Chongqing, PR China;2. Department of Obstetrics and Gynecology, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa;3. Department of Ultrasound, Huanggang Central Hospital, Huanggang City, Hubei 438000, China;4. Shanghai First Maternity and Infant Health Hospital, Shanghai, PR China;1. Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing, 400016, China;2. State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China;1. The Institute of Ultrasound Engineering in Medicine, Chongqing Medical University, 1 Yixueyuan Road, Box 153, Chongqing 400016, China;2. Clinical Center for Tumor Therapy, The 2nd Hospital, Chongqing Medical University, 76 Linjiang Road, Chongqing 400010, China;3. Department of Obstetrics of Chongqing Haifu Hospital, Qingsong Road, Renhe, Yubei District, Chongqing 401121, China;1. Department of Radiology, Isala hospital, Zwolle, the Netherlands;2. Department of Obstetrics and Gynecology, Isala hospital, Zwolle, the Netherlands;3. Department of Innovation and Science, Isala hospital, Zwolle, the Netherlands;4. Division Woman and Baby, University Medical Center Utrecht, Utrecht, the Netherlands;5. Center for Imaging Sciences, University Medical Center Utrecht, Utrecht, the Netherlands |
| |
| Abstract: | ObjectivesTo investigate the relationship between the features of magnetic resonance imaging (MRI) on T2 weighted images (T2WI) and the therapeutic efficacy of high intensity focused ultrasound (HIFU) on adenomyosis.Materials and methodsFrom January 2011 to November 2015, four hundred and twenty-eight patients with symptomatic adenomyosis were treated with HIFU. Based on the signal intensity and the number of hyperintense foci in the adenomyotic lesions on T2WI, the patients were classified into groups. The day after HIFU ablation patients underwent contrast-enhanced MRI and a comparison was made of non-perfused volume (NPV) ratio, energy efficiency factor (EEF), treatment time, sonication time, and adverse effects.ResultsNo significant difference in terms of HIFU treatment settings and results was observed between the group of patients with hypointense adenomyotic lesions and the group with isointense adenomyotic lesions (P > 0.05). However, the sonication time and EEF were significantly higher in the group with multiple hyperintense foci compared to the group with few hyperintense foci. The NPV ratio achieved in the lesions with multiple hyperintenese foci was significantly lower than that in the lesions with few hyperintense foci (P < 0.05). No significant difference was observed in the rate of adverse effects between the two groups.ConclusionsBased on our results, the response of the adenomyotic lesions to HIFU treatment is not related to the signal intensity of adenomyotic lesions on T2WI. However, the number of the high signal intensity foci in the adenomyotic lesions on T2WI can be considered as a predictive factor to help select patients for HIFU treatment. |
| |
| Keywords: | High intensity focused ultrasound (HIFU) Magnetic resonance imaging (MRI) Adenomyosis Signal characteristics Ablative efficiency |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
