Residual tumour detection in post-treatment granulation tissue by using advanced diffusion models in head and neck squamous cell carcinoma patients |
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| Institution: | 1. Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan;2. Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan;3. Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan;4. The Global Station for Quantum Medical Science and Engineering, Global Institution for Collaborative Research and Education, Sapporo, Japan;1. Nuclear Medicine Unit, San Giuseppe Moscati Hospital, Avellino, Italy;2. Nuclear Medicine and Molecular Imaging Unit, Veneto Institute of Oncology IOV—IRCCS, Padova, Italy;3. Division of Medical Oncology, San Giuseppe Moscati Hospital, Avellino, Italy;4. Department of Advanced Biomedical Sciences, University of Naples Federico II, Napoli, Italy;1. Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43 Gil, Songpa-gu, Seoul 138-736, Republic of Korea;2. Department of Thoracic and Cardiovascular Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea;1. Russell H. Morgan Department of Radiology and Radiological Science, Division of Vascular and Interventional Radiology, The Johns Hopkins Hospital, Sheikh Zayed Tower, Suite 7203, 1800 Orleans St, Baltimore, MD, USA 21287;2. Department of Diagnostic and Interventional Radiology, Charite Universitätsmedizin, Berlin, Germany;3. U/S Imaging and Interventions (UII), Philips Research North America, Briarcliff Manor, NY, USA;4. Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA;1. Department of Radiology, Huntington Hospital, Northwell Health, 270 Park Avenue, Huntington, NY 11743, USA;2. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Boulevard, Hempstead, NY 11549, USA;3. Department of Radiology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Boulevard, Hempstead, NY 11549, USA;1. Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital,No. 106 Zhongshan Er Road, 510080, Guangzhou, China;2. Southern Medical University Graduate School,No. 1023-1063 ShatainanRoad, 510515, Guangzhou, China |
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| Abstract: | PurposeTo evaluate the detectability of the residual tumour in post-treatment granulation tissue using parameters obtained with an advanced diffusion model in patients with head and neck squamous cell carcinoma (HNSCC) treated by chemoradiation therapy.Materials and methodsWe retrospectively evaluated 23 patients with HNSCC after the full course of chemoradiation therapy. The diffusion-weighted image (DWI) acquisition used single-shot spin-echo echo-planar imaging with 11 b-values (0–1000). We calculated 10 DWI parameters using a mono-exponential model, a bi-exponential model, a stretched exponential model (SEM), a diffusion kurtosis imaging (DKI) model and a statistical diffusion model (SDM) in the region of interest (ROI) placed on the post-treatment granulation tissue. The presence of residual tumour was determined by histological findings or clinical follow-up.ResultsAmong the 23 patients, seven patients were revealed to have residual tumour. The univariate analysis revealed significant differences in six parameters between the patients with and without residual tumour. From the receiver operating characteristic curve analysis, the highest area under curve was detected in the center of the Gaussian distribution of diffusion coefficient (Ds) obtained by the SDM. The multivariate analysis revealed that the Ds and diffusion heterogeneity (α) obtained by the SEM were predictors for the presence of residual tumour.ConclusionDWI parameters obtained by advanced fitting models will be one of the diagnostic tools for the detection of residual tumour. |
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| Keywords: | Diffusion weighted imaging Advanced diffusion model Residual tumour Post-treatment granulation tissue Head and neck squamous cell carcinoma |
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