Spindle cell lesions of the breast: Multimodality imaging and clinical differentiation of pathologically similar neoplasms |
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| Affiliation: | 1. Breast Imaging Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milano, Italy;2. Medical Physics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milano, Italy;3. Unit of Medical Statistics, Biometry and Bioinformatics, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milano, Italy;4. Information and Communication Technology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milano, Italy;1. Department of Diagnostic Imaging, Rhode Island Hospital, Alpert Medical School of Brown University, Main Bldg, 3rd floor, 593 Eddy St, Providence, RI 02903;2. Beth Israel Deaconness Medical Center, Harvard Medical School, Boston, Massachusetts;3. Dartmouth Hitchcock Medical Center, Hanover, New Hampshire |
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| Abstract: | Spindle cell lesions of the breast comprise a wide-range of entities including reactive, benign and malignant proliferations. They can be pathologically challenging to differentiate as there is often immunohistochemical and morphologic similarities with characteristic spindle shaped cellular patterns. Radiological and pathological correlation is essential. Radiology detects, defines the size and extent, and assists in localizing the lesions. Pathology confirms the diagnosis and provides prognostic parameters. Familiarity with the clinicoradiological features of these diagnostically challenging lesions helps to establish an accurate pathological diagnosis and subsequent clinical decision making. |
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| Keywords: | Spindle cell lesions Carcinoma Invasive ductal carcinoma subtypes |
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