丝裂原活化蛋白激酶家族与病理性疼痛

病理性疼痛包括炎性痛和神经病理性痛。炎性痛是由创伤、细菌或病毒感染及外科手术等引起的外周组织损伤导致的炎症而引起的疼痛;神经病理性疼痛是由于外周或中枢神经系统的直接损伤或功能紊乱引起的疼痛,其共同的临床表现有自发性疼痛、痛觉过敏、触诱发痛等。许多脊髓或高级中枢神经病理生理的改变都可引起或参与病理性神经痛的形成。目前的研究认为,脊髓背角神经元及脊髓胶质细胞丝裂原活化蛋白激酶家族活化与病理性疼痛有关1,2]。现就MAPKs在病理性疼痛的发生、发展过程中所起的作用作一综述。1 MAPKsMAPKs在所有真核细胞中均有表…

Roles of mitogen-activated protein kinases and neuropathic pain

Management of pathological pain is a major clinical challenge.The identification of the neurobiological mechanisms for neuropathic pain and offering the possibility of better diagnostic sensitivity and a more rational basis for therapy are always the challenging subject on the leading edge of modern medicine.There are several different intercellular signal transduction pathways being involved in the establishment and the maintenance of pathological pain converge into mitogen-activated protein kinases pathway.MAPK family plays a pivotal role in central sensitization.Therefore,further employ MAPK family could offer not only the possibility of investigating pathological pain deeply,but also to provide a new therapeutic potential for pathological pain.