慢性化脓性中耳炎病原菌及耐药性分析

目的研究慢性化脓性中耳炎的主要病原菌种类及对抗生寨的耐药情况。方法对132例慢性化脓性中耳炎患者的脓性分泌物进行细菌培养并对分离的病原菌进行药物敏感试验。结果分离出病原菌152株，以金黄色葡萄球菌（49株）和铜绿假单胞菌（25株）为主，真菌5株。金黄色葡萄球菌对喹诺酮类敏感，敏感率为79．6％。铜绿假单胞菌对头孢他啶和喹诺酮类敏感，敏感率分别为84％和64％。结论金黄色葡萄球菌和铜绿假单胞菌是聊城地区慢性化脓性中耳炎主要致病菌，二者均对喹诺酮类敏感，铜绿假单胞菌亦对三代头孢类的头孢他啶敏感。临床医师在对慢性化脓性中耳炎患者治疗时应根据细菌培养和药敏结果用药，准确有效的治疗，以防耐药菌株的发生。真菌在慢性化脓性中耳炎致病菌中不容忽视。

Analysis of pathogenic bacteria and its drug resistance in chronic suppurative otitis media

OBJECTIVE To study the pathogenic bacteria and its resistance to antibiotics in chronic suppurative otitis media. METHODS Secretion from 132 cases with chronic suppurative otitis media were cultured. Drug sensitivity tests were done to separate pathogenic bacteria. RESULTS 152 strains pathogenic bacteria were isolated from middle ear secretion. The main pathogenic bacteria were staphylococcus aureus (49 strains), pseudomonas aeruginosa (25 strains) and fungus (5 strains). Staphylococcus aureus was sensitive to fluorquinolones, and the sensitivity rate was 79.6 %. Pseudomonas aeruginosa was sensitive to fluoroquinolones and floxacin, and the sensitivity rates were 84 % and 64 %. CONCLUSION Staphylococcus aureus and pseudomonas aeruginosa are main pathogens of chronic suppurative otitis media in our region. Both of them are sensitive to fluorquinolones. Meanwhile, pseudomonas aeruginosa is also sensitive to ceftazidime of the third cephalosporins. So doctors should choose the sensitive antibiotics for treatment of the chronic suppurative otitis media, that may avoid the bacteria with drug resistance come into being. The fungus can not be neglected as the pathogen in chronic suppurative otitis media.