Polymorphism of dopamine D2 receptor (TaqIA, TaqIB, and-141C Ins/Del) and dopamine degradation enzyme (COMT G158A, A-278G) genes and extrapyramidal symptoms in patients with schizophrenia and bipolar disorders |
| |
| Authors: | Lafuente Amalia Bernardo Miquel Mas Sergi Crescenti Anna Aparici Monica Gasso Patricia Deulofeu Ramon Mane Anna Catalan Rosa Carne Xavier |
| |
| Institution: | Department of Pharmacology, University of Barcelona, IDIBAPS, Casanova 143, E-08036 Barcelona, Spain. amalialafuente@ub.edu |
| |
| Abstract: | OBJECTIVE: The relationship is examined of the dopamine D2 receptor (DRD2) polymorphism (TaqIA, TaqIB, -141 C Ins/Del) and the catechol-O-methyltransferase (COMT) polymorphism (A-278G, G158A) to the risk of antipsychotic-induced extrapyramidal symptoms (EPS) in schizophrenia and bipolar disorders. Participants comprised 80 cases presenting with EPS (Simpson-Angus Scale score >3) and 188 controls presenting without EPS (Simpson-Angus Scale score
|
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
