乌司他丁在创伤性急性肺损伤治疗中的作用

目的探讨乌司他丁对创伤性急性肺损伤的治疗作用。方法选择60例创伤性急性肺损伤患者,随机分为乌司他丁治疗组(n=30)和对照组(n=30),对照组接受常规治疗。乌司他丁治疗组在常规治疗基础上静脉滴注乌司他丁50000 U/kg,1次/d,连用3 d,观察两组的临床疗效并检测治疗前及治疗第2天、第3天的血清TNF-α、IL-6和IL-8水平变化。结果乌司他丁治疗组与对照组在治疗前TNF-α、IL-6和IL-8水平无差异。治疗后乌司他丁治疗组的TNF-α、IL-6和IL-8水平下降较对照组明显(P<0.05)。乌司他丁治疗组治疗后呼吸频率(RR)、氧分压(PaO2)、二氧化碳分压(PaCO2),氧合指数(PaO2/F iO2)与对照组差异有统计学意义(P<0.05)。结论乌司他丁可显著抑制机体炎症介质的产生,创伤性急性肺损伤早期应用治疗效果明显。

Therapeutic Value of Ulinastatin in Traumatic Acute Lung Injury

Objective To observe the therapeutic value in traumatic acute lung injury using ulinastatin.Methods Sixty patients with traumatic acute lung injury were randomly divided into ulinastatin group(n=30) and routine group(n=30).Both groups were given routine treatment,while the patients of the ulinastatin group were given ulinastatin(50,000 U/kg,intravenous drip,once per 24 hours,3 days) in addition.The efficacy in both the groups were assessed,and their serum tumor necrosis factor(TNF)-α,interleukin(IL)-6 and IL-8 levels were measured on the admission day and on the second and the third day.Results TNF-α,IL-6 and IL-8 levels were not different between the two groups before treatment,but they reduced more significantly after treatment in the ulinastatin group than in the routine group(P<0.05).There were significantly differences in respiratory rate(RR),arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2) and PaO2/FiO2 after treatment between the two groups(P<0.05).Conclusion Ulinastatin significantly inhibits the production of inflammatory cytokines.Early adminstration of ulinastatin can play an important role in the treatment of acute lung injury.