首页 | 本学科首页   官方微博 | 高级检索  
     


Coenzyme Q10 protects neurons against neurotoxicity in hippocampal slice culture
Authors:Won Ran  Lee Kyung Hee  Lee Bae Hwan
Affiliation:Department of Biomedical Laboratory Science, Dongseo University, Busan, Korea.
Abstract:This study investigated the neuroprotective effects of coenzyme Q10 (CoQ10) against oxidative stress induced by kainic acid (KA) in organotypic hippocampal slice culture of rats. Cultured slices were injured by exposure to 5 μM of KA for 18 h and then treated with different concentrations of CoQ10. Neuronal cell death measured as propidium iodide uptake was reduced at 24 h after treatment with 1 μM of CoQ10. We also observed an increased number of surviving CA3 neurons in 0.1 and 1 μM concentrations of CoQ10-treated groups using cresyl violet staining. CoQ10 (0.01, 0.1, and 1 μM) treatment significantly decreased the 2',7'-dichlorofluorescein fluorescence and the expression of NQO1 in the CoQ10-treated groups was significantly lower than that in the KA-only group. These results suggest that CoQ10 may protect hippocampal neurons against oxidative stress.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号