| 川芎嗪关节腔内注射对膝骨关节炎的治疗作用 |
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| 引用本文： | 胡建中,罗承耀,康明,吕红斌,雷光华,戴祝. 川芎嗪关节腔内注射对膝骨关节炎的治疗作用[J]. 中南大学学报(医学版), 2006, 31(4): 591-594 |
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| 作者姓名： | 胡建中 罗承耀 康明 吕红斌 雷光华 戴祝 |
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| 作者单位： | 中南大学湘雅医院骨科,长沙,410008;深圳市流花医院骨科,深圳,510008 |
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| 基金项目： | 湖南省自然科学基金;湖南省卫生厅科研项目 |
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| 摘 要： | 目的：探讨川芎嗪关节腔内注射对膝骨关节炎的治疗作用。方法：7l例膝骨关节炎患者随机分为两组，分别予盐酸川芎嗪注射液或透明质酸钠注射液膝关节腔内注射，每周1次，连续5周。随访3月。参照Lequesne骨关节炎严重性和活动性评估法制定观察表，分别对两组患者治疗前后Lequesne评分及疗效进行比较。结果：透明质酸钠组在治疗1周后Lequesne评分较治疗前有明显降低（P〈0．01），川芎嗪组在治疗3周后Lequesne评分明显降低（P〈0．01）。治疗5周后，川芎嗪组总有效率为82．1％，透明质酸钠组总有效率为87．2％，两组疗效差异无统计学意义（P〉0．05）。两组在治疗过程中均未见明显的不良反应。结论：川芎嗪关节腔内注射对膝骨关节炎具有治疗作用，且无明显不良反应，但起效较慢。
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| 关 键 词： | 骨关节炎 川芎嗪 关节腔内注射 |
| 文章编号： | 1672-7347（2006）04-0591-04 |
| 收稿时间： | 2005-04-21 |
| 修稿时间： | 2005-04-21 |
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| HU Jian-zhong,LUO Cheng-yao,KANG Ming,L Hong-bin,LEI Guang-hua,DAI Zhu.
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| Authors: | HU Jian-zhong LUO Cheng-yao KANG Ming L Hong-bin LEI Guang-hua DAI Zhu |
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| Affiliation: | Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410078, China. hjz3734@vip.sina.com.cn |
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| Abstract: | OBJECTIVE: To evaluate the therapeutic effects of intraarticular injection of ligustrazine on knee osteoarthritis (OA). METHODS: Seventy-one cases of knee osteoarthritis (82 knees) were randomly divided into ligustrazine (LI) group and sodium hyaluronate (SH) group. The patients were intraarticularly injected ligustrazine or sodium hyaluronate once a week for 5 consecutive weeks, and were followed-up for 3 months. Lequesneos protocol for the evaluation of OA severity and activity was used. The therapeutic effects and changes of Lequesneos index were observed after the treatment. RESULTS: There was significant decrease in Lequesneos index in SH group after the treatment (P<0.01), but not in LI group (P>0.05). Three weeks later, there was significant decrease in Lequesneos index in both groups after the treatment (P<0.01), with no significant difference between SH and LI group (P>0.05). After the 5-week treatment, the efficacy rate of the LI group was 82.1%, and that of the SH group was 87.2%. No serious toxic or side effect was observed during the treatment and the follow-up. CONCLUSION: Intraarticular injection of ligustrazine has a therapeutic effect on knee OA. No adverse effect is observed, but it needs long time to take effect. |
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| Keywords: | osteoarthritis ligustrazine intraarticular injection |
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