| 老龄大鼠脑缺血/再灌注微血管生成的变化意义 |
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| 引用本文： | 李建生,刘轲,周友龙,高剑峰,杨歆科,赵跃武,刘政国,刘敬霞.老龄大鼠脑缺血/再灌注微血管生成的变化意义[J].中风与神经疾病杂志,2010,27(2). |
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| 作者姓名： | 李建生 刘轲 周友龙 高剑峰 杨歆科 赵跃武 刘政国 刘敬霞 |
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| 作者单位： | 河南中医学院老年医学研究所,河南郑州,450008 |
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| 基金项目： | 国家自然科学基金资助项目(30772842); 河南省杰出青年基金资助项目(0612000700) |
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| 摘 要： | 目的探讨老年脑缺血/再灌注(I/R)脑微血管生成的意义。方法SD雄性青年和老龄大鼠,随机分为青年假手术组、青年模型组、老龄假手术组、老龄模型组;模型组分为脑缺血3h、I/R1d、3d、6d、12d时间点。采用线栓法制备局灶性脑I/R模型,测定脑微血管密度(MVD)、血管场面积、神经细胞凋亡数以及脑组织病理改变等。结果老龄模型组I/R6d、12d MVD较老龄假手术组降低(P<0.05,P<0.01),I/R 1d血管场面积较老龄假手术组增高(P<0.05);与青年组同时间点分别比较,老龄假手术组MVD增高(P<0.01),老龄模型组I/R 1d、3d、6d、12d大鼠MVD、血管场面积均降低(P<0.05,P<0.01)。老龄模型组MVD自脑缺血3h持续下降至I/R 12d;血管场面积于I/R 1d达峰值,后逐步下降。老龄模型组I/R 1d、3d、6d、12d大鼠神经细胞凋亡数较其假手术组增多(P<0.05,P<0.01);与青年组同时间点分别比较,老龄假手术组及模型组I/R3d、6d神经细胞凋亡数增多(P<0.01)。老龄模型组神经细胞凋亡数I/R 3d达峰值,I/R 3~12d逐渐减少。脑组织病理改变方面...
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| 关 键 词： | 老龄 大鼠 脑缺血/再灌注 血管生成 |
The significance of age-related changes of cerebral angiogenesis after cerebral ischemia/reperfusion in aged rats |
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| LI Jian-sheng,LIU Ke,ZHOU You-long,et al..The significance of age-related changes of cerebral angiogenesis after cerebral ischemia/reperfusion in aged rats[J].Journal of Apoplexy and Nervous Diseases,2010,27(2). |
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| Authors: | LI Jian-sheng LIU Ke ZHOU You-long |
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| Institution: | LI Jian-sheng,LIU Ke,ZHOU You-long,et al.(Geriatrics Department,Henan College of Traditional Chinese Medicine,Zhengzhou 450008,China) |
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| Abstract: | Objective To study the significance of cerebral angiogenesis after cerebral ischemia/reperfusion in aged rats.Methods Young and aged masculine SD rats were randomly divided into sham operated group and model group.Model group were subjected to 3h of middle cerebral artery occulsion with the intraluminal filament technique,then followed by reperfusion of 1d,3d,6d and 12d.The microvessel density(MVD) of brain tissue,sum area of lumens,apoptosis counts of nerve cells and brain cell ultrastructure were examined... |
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| Keywords: | Aged Rats Cerebral ischemia/reperfusion Angiogenesis |
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