| 胰岛素对单核/巨噬源性泡沫细胞ACAT-1表达的影响 |
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| 引用本文： | 白智峰,成蓓,李长运,何平,毛晓波.胰岛素对单核/巨噬源性泡沫细胞ACAT-1表达的影响[J].中华内分泌代谢杂志,2005,21(5):473-474. |
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| 作者姓名： | 白智峰 成蓓 李长运 何平 毛晓波 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院心内科
430022武汉(白智峰，成蓓，李长运，何平)，华中科技大学同济医学院附属协和医院心内科 430022武汉(毛晓波) |
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| 基金项目： | 国家自然科学基金资助项目(30170378) |
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| 摘 要： | 研究胰岛素对单核/巨噬细胞转分化和泡沫细胞形成过程中酰基辅酶A:胆固醇酰基转移酶-1(ACAT-1)表达的影响,发现胰岛素对ACAT-1酶的活性、蛋白、mRNA表达均有增强作用。
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| 关 键 词： | 胰岛素 甾醇O-酰基转移酶 巨噬细胞 |
| 收稿时间： | 2004-04-20 |
| 修稿时间： | 2004年4月20日 |
Effects of insulin on expression of acyl-coenzyme A:cholesterol acyltransferases-1 in cultured human monocyte/macrophage-derived foam cells |
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| BAI Zhi-feng, CHENG Bei, LI Chang-yun, HE Ping, MAO Xiao-bo..Effects of insulin on expression of acyl-coenzyme A:cholesterol acyltransferases-1 in cultured human monocyte/macrophage-derived foam cells[J].Chinese Journal of Endocrinology and Metabolism,2005,21(5):473-474. |
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| Authors: | BAI Zhi-feng CHENG Bei LI Chang-yun HE Ping MAO Xiao-bo |
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| Institution: | Department of Cardiology, Union Hospital Affilliate-d to Tongji Medical College of Huazhong University of Technology and Science, Wuhan 430022 |
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| Abstract: | During the monocyte-macrophage differentiation and foam cell formation, the effects of insulin on expression of acyl-CoA:cholesterol acyltransferases-1 (ACAT-1) were investigated. The results showed that insulin increased significantly enzyme activity, protein and mRNA expression of ACAT-1. |
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| Keywords: | Insulin Sterol O-acyltransferase Macrophages |
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