| 吡柔比星-碘油乳剂不同配比特性的实验研究 |
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| 引用本文： | 徐力扬,李京雨,刘明,张永田. 吡柔比星-碘油乳剂不同配比特性的实验研究[J]. 中国肿瘤临床, 2002, 29(4): 262-264 |
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| 作者姓名： | 徐力扬 李京雨 刘明 张永田 |
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| 作者单位： | 北京军区总医院放射诊断科,北京市,100700 |
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| 摘 要： | 目的：研究肝动脉化疗栓塞治疗肝癌时所使用吡柔比星－碘油乳剂的最佳配比方案。方法：多种水溶剂和造影剂溶解吡柔比星后以不同油水比例与碘化油制成7种乳剂。肉眼和显微镜观察各样本物理稳定性。用控制应力流变仪检测样本粘滞度。结果：吡柔比星经生理盐水和非离子型造影剂溶解后与碘化油制成的乳剂（NNTLE）性质稳定，粘滞度较其它乳剂低。油水比2：1的NNTLE稳定性最好，粘滞度适中。结论：油水比2：1的NNTLE是较为理想的吡柔比星－碘油栓塞剂配制方法，利于肝癌的肝动脉化疗栓塞治疗。
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| 关 键 词： | 吡柔比星 碘化油 乳剂 栓塞治疗 肝癌 配比 实验研究 |
| 文章编号： | 1000-8179(2002)04-0262-03 |
| 修稿时间： | 2001-08-30 |
Pirarumbicin-Lipiodol Emulsion for TACE |
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| Xu Liyang Li Jingyu Liu Ming et al. Pirarumbicin-Lipiodol Emulsion for TACE[J]. Chinese Journal of Clinical Oncology, 2002, 29(4): 262-264 |
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| Authors: | Xu Liyang Li Jingyu Liu Ming et al |
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| Affiliation: | Xu Liyang Li Jingyu Liu Ming et al Department of Radiodiagnosis,General Hospital of Beijing Military District of PLA,Beijing |
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| Abstract: | Objective:To explore the best way to prepare Pirarumbicin(THP)-Lipiodol(LIP)emul sion for transarterial chemoembolization(TACE)therapy of hepatocellular carcinoma.Methods:Several types of emulsion were prepared using LIP and THP dissolved in different solvents(nor-mal saline,glucose solution,non-ion contrast,ion contrast and distilled water).Physical stability of each preparation was examined macroscopically and microscopically.Viscosity of each sample was measured with dynamic stress rheometer.Results:The normal saline and non-ion contrast dis solved THP with LIP emulsion(NNTLE)had higher stability and low viscosity than other emul -sions.Its physical characteristics could be affected obviously by oil-water rate.In an oil-water ratio of2 :1,the NNTLE presented the highest stability and a moderate viscosity.Con clusion:NNTLE with the oil-water ratio of2 :1is suggested to be a proper embolization agent for TACE. |
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| Keywords: | Pirarumbicin Lipiodol Emulsion Embolization Hepatocellular carcinoma |
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