夜戴型非球面角膜塑形镜对眼表微环境的影响

夜戴型非球面角膜塑形镜(night-wear aspheric orthokeratology lens)，以下简称OK镜，利用夜间睡眠时间矫正视力，是目前为数不多的可以让近视的孩子白天不戴眼镜的方法，所以经常作为8～16岁近视人群临床上首选推荐。OK镜通过对眼表面产生逆向几何作用力的压迫作用，使得角膜曲率降低，从而达到暂时性的矫正近视的作用。目前作为一种公认的治疗青少年近视的非手术方法之一，非球面角膜塑形镜的镜片材质和验配水平一直在不断的创新和升级。OK镜片直接覆盖于眼表，长期配戴会对眼表微环境造成一定影响，比如睑板腺、泪膜、结膜、角膜以及眼表微生物等，甚至可能造成眼表微环境的失衡，从而导致眼表疾病的发生和发展。本文旨在分析配戴非球面角膜塑形镜对眼表睑板腺形态、泪膜的形态与功能、结膜微循环、角膜细胞形态、眼表微生物等因素的影响，以指导临床医生对青少年配戴角膜塑形镜时给予全面考量，增加夜戴型非球面角膜塑形镜的安全性和有效性。

Analysis of the influence of night-wear aspheric orthokeratology lens on ocular surface microenvironment

Night-wear aspheric orthokeratology lens(refers to OK lens)is used to correct vision while sleeping at night, which is one of the few ways to prevent myopic children from wearing glasses during the day, so often recommended as the first choice in clinical practice for the myopic population of 8-16 years old. The main effect of OK lens is producing reasonable compression on the surface of the eye to reduce the curvature of the cornea. At present, as a recognized non-surgical method for the treatment of juvenile myopia, the lens material and the optometry level of OK lens have been continuously innovated and upgraded. Meanwhile,because OK lens directly cover the ocular surface, so long-term wearing definitely affects the ocular surface microenvironment, including meibomian glands, tear film, conjunctiva, cornea, ocular surface microorganisms and so on, and even causes the imbalance of these ocular surface microenvironments, thereby leading to the occurrence and development of ocular surface diseases. In order to expect clinicians to give comprehensive consideration when wearing OK lens for teenagers and increase the safety and effectiveness of wearing OK lens, this article analyzed the effects of wearing OK lens on ocular surface meibomian gland morphology, tear film morphology and function, conjunctival microcirculation, corneal cell morphology, ocular surface microorganisms and other factors.