疏风解毒胶囊联合消银颗粒治疗寻常型银屑病(血热证)的临床研究

目的观察疏风解毒胶囊联合消银颗粒治疗寻常型银屑病(血热证)的临床疗效。方法选取2013年6月—2015年6月来周口市中心医院皮肤科就诊的寻常型银屑病患者98例,按就诊时间分为对照组(46例)和治疗组(52例)。对照组口服消银颗粒,1袋/次,3次/d。治疗组在对照组治疗基础上口服疏风解毒胶囊,4粒/次,3次/d。两组均连续治疗2个月。观察两组的临床疗效,比较两组治疗前后肿瘤坏死因子α(TNF-α)、白细胞介素4(IL-4)、白细胞介素17(IL-17)、银屑病皮损面积严重指数(PASI)评分的变化情况。结果治疗后,对照组和治疗组的总有效率分别为67.4%、84.6%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者TNF-α、IL-4、IL-17、PASI评分均较治疗前显著降低,同组治疗前后差异有统计学意义(P0.05);治疗后,治疗组TNF-α、IL-4、IL-17、PASI评分低于对照组,两组比较差异具有统计学意义(P0.05)。结论疏风解毒胶囊联合消银颗粒治疗寻常型银屑病(血热证)具有较好的临床疗效,可降低PASI评分和相关因子水平,具有一定的临床推广应用价值。

Clinical study on Shufeng Jiedu Capsules compared with Xiaoyin Granules in treatment of psoriasis vulgaris (blood-heat syndrome)

Objective To observe the efficacy of Shufeng Jiedu Capsules compared with Xiaoyin Granules in treatment of psoriasis vulgaris (blood-heat syndrome).Methods Patients (98 cases) with psoriasis vulgaris in Zhoukou Central Hospital from June 2013 to June 2015 were divided into control (46 cases) and treatment (52 cases) groups according to the clinic time. Patients in the control group werepoadministered with Xiaoyin Granules, 1 bag/time, three times daily. Patients in the treatment group werepoadministered with Shufeng Jiedu Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for two months. After treatment, the clinical efficacy was evaluated, and the changes of TNF-α, IL-4, IL-17, and PASI scores before and after treatment in two groups were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 67.4% and 84.6%, respectively, and there was difference between two groups (P < 0.05). After treatment, TNF-α, IL-4, IL-17, and PASI scores significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, TNF-α, IL-4, IL-17, and PASI scores in the treatment group were lower than those in the control group, and there was difference between two groups (P < 0.05).Conclusions Shufeng Jiedu Capsules compared with Xiaoyin Granules has significant clinical effect in treatment of psoriasis vulgaris (blood-heat syndrome), and can reduce the PASI scores and related factors, which has a certain clinical application value.