扩散加权成像评价胎儿轻度侧脑室扩张

目的 探讨ADC值对胎儿轻度侧脑室扩张的诊断价值。方法 对15胎轻度侧脑室扩张胎儿（侧脑室扩张组）及15胎侧脑室无扩张的胎儿（对照组）行DWI扫描，测量双侧额叶、顶叶、颞叶、枕叶白质、基底核、丘脑及小脑ADC值，比较2组各脑区ADC值差异及轻度侧脑室扩张胎儿左侧及右侧各脑区ADC值的差异。分析所有胎儿各脑区ADC值与孕周的相关性、侧脑室扩张胎儿侧脑室宽度与孕周的相关性。结果 与对照组比较，轻度侧脑室扩张组双侧额叶、双侧顶叶白质ADC值下降（P均<0.05）。侧脑室扩张胎儿左侧与右侧各脑区ADC值差异均无统计学意义（P均>0.05）。相关分析显示所有胎儿双侧枕叶、双侧基底核区、双侧丘脑、双侧小脑及左侧颞叶ADC值与孕周呈负相关，侧脑室扩张胎儿侧脑室宽度与孕周呈正相关（r=0.635，P=0.011）。结论 轻度侧脑室扩张胎儿额叶、顶叶ADC值下降，ADC值对检测潜在脑部损伤较敏感，有助于诊断胎儿侧脑室扩张。

Diffusion weighted imaging research in fetus with mild ventriculomegaly

Objective To explore the diagnostic value of ADC values in fetus with mild ventriculomegaly. Methods Fifteen fetuses with mild ventriculomegaly (mild ventriculomegaly group) and fifteen healthy controls (control group) were scanned with DWI. The ADC values in bilateral frontal lobes, parietal lobes, temporal lobes, occipital lobes, basal ganglia, thalamus and cerebella were measured. The ADC values of mild ventriculomegaly group were compared with those of control group. And the ADC values in left regions were compared with those in right regions of fetuses with mild ventriculomegaly. The correlation between ADC values of all fetuses and gestational age, as well as the correlation between the diameters of ventriculomegaly in feutes with mild ventriculomegaly and gestational age were analyzed. Results Compared with control group, ADC values were lower in bilateral frontal lobes and parietal lobes in mild ventriculomegaly group (all P<0.05). There were no significant differences of ADC values between left regions and right regions (all P>0.05). Correlation analysis showed that ADC values of all fetuses in bilateral occipital lobes, basal ganglia, thalamus, cerebella and left temporal lobe were negatively correlated with gestational age. The diameters of ventriculomegaly were positively correlated with gestational age (r=0.635, P=0.011). Conclusion The ADC values decrease in frontal lobes and parietal lobes in fetuses with mild ventriculomegaly. The ADC value may be more sensitive for detecting potential damage of brain, which is helpful for the diagnosis of fetus ventriculomegaly.