松龄血脉康联合坎地沙坦酯治疗更年期女性阴虚阳亢型高血压的疗效观察

目的探讨松龄血脉康胶囊联合坎地沙坦酯片治疗更年期女性阴虚阳亢型高血压的疗效观察。方法选取2015年3月—2015年10月在天津市中医药研究院附属医院就诊的阴虚阳亢型更年期女性原发性高血压患者70例,随机分为对照组和治疗组,每组各35例。对照组口服坎地沙坦酯片,8 mg/次,1次/d。治疗组在对照组基础上口服松龄血脉康胶囊,1.5 g/次,3次/d。两组患者均持续治疗8周。观察两组的临床疗效,比较两组的血压和中医证候积分情况。结果治疗后,对照组和治疗组的血压疗效总有效率分别为74.28%、85.71%,中医证候疗效总有效率分别为68.57%、88.57%,两组比较差异有统计学意义(P0.05)。治疗后,两组收缩压和舒张压均明显降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组眩晕、头痛、五心烦热、心悸失眠的中医证候积分均明显下降,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。结论松龄血脉康胶囊联合坎地沙坦酯片治疗更年期女性阴虚阳亢型高血压具有较好的临床疗效,能显著降低血压,改善临床症状,具有一定的临床推广应用价值。

Clinical observation of Songling Xuemaikang Capsules combined with candesartan in treatment of climacteric hypertension with Yin deficiency and Yang hyperactivity

Objective To observe the clinical effect of Songling Xuemaikang Capsules combined with Candesartan Cilexetil Tablets in treatment of climacteric hypertension with Yin deficiency and Yang hyperactivity. Methods Climacteric women (70 cases) with hypertension hyperactivity in Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital from March 2015 to October 2015 were randomly divided into control and treatment groups, and each group had 35 cases. Patients in the control group were po administered with Candesartan Cilexetil Tablets, 8 mg/time, once daily. Patients in the treatment group were po administered with Songling Xuemaikang Capsules on the basis of the control group, 1.5 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and blood pressure and Traditional Chinese Medicine syndrome scores in two groups were compared. Results After treatment, the clinical efficacies of blood pressure in the control and treatment groups were 74.28% and 85.71%, respectively, and the clinical efficacies of Traditional Chinese Medicine syndrome in the control and treatment groups were 68.57% and 88.57%, respectively, and there were difference between two groups (P<0.05). After treatment, systolic pressure and diastolic pressure in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the Traditional Chinese Medicine syndrome scores of dizziness, headache, feverish sensation over the five centers (palms, soles, and chest), palpitation, and insomnia in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Songling Xuemaikang Capsules combined with Candesartan Cilexetil Tablets has clinical curative effect in treatment of climacteric hypertension with Yin deficiency and Yang hyperactivity, can significantly decrease blood pressure, and improve clinical symptoms, which has a certain clinical application value.