膀胱内翻性乳头状瘤和膀胱尿路上皮癌CEUS与微血管密度的相关性

目的 探讨膀胱内翻性乳头状瘤（IPB）与膀胱尿路上皮癌的（BUC）CEUS时间-强度曲线（TIC）参数与微血管密度（MVD）的相关性。方法 回顾性分析经病理证实的IPB患者30例和BUC患者50例的临床和CEUS表现，采用QLab分析软件获得IPB和BUC的TIC参数，包括上升时间（RT）、平均渡越时间（MTT）、峰值强度（PI）、半洗漱时间（TPH）、上升斜率（WIS）、达峰时间（TP）、半降支斜率（DS），并进行统计学分析。对手术标本进行抗CD34因子免疫组化染色测量MVD，分析CEUS的TIC参数与MVD的相关性。结果 IPB和BUC的CEUS定量参数中，PI、TPH、TP、DS比较差异均有统计学意义（P<0.05）。BUC的MVD明显高于IPB（P<0.05）。各TIC参数中，TPH和DS与MVD均存在相关性（r_s=0.74、-0.81，P均<0.05）。结论 CEUS在IPB与BUC的鉴别诊断中具有一定的临床价值；TIC参数可定量评估肿瘤内微血管生成情况。

Correlation of CEUS and microvessel density in inverted papilloma of bladder and bladder urothelial carcinoma

Objective To explore the correlation between time-intensity curve (TIC) parameters of CEUS and microvessel density (MVD) of inverted papilloma of bladder (IPB) and bladder urothelial carcinoma (BUC). Methods Clinical and CEUS characteristics of 30 patients with IPB and 50 patients with BUC confirmed by pathology were retrospectively analyzed. CEUS TIC parameters included rise time (RT), mean transit time (MTT), peak intensiy (PI), time from peak to one half (TPH), wash in slope (WIS), time to peak (TP), semi-descending slope (DS) were acquired by QLab software and statistical analysis was carried out. The MVD of the resectioned tissue specimens were quantified via immunohistochemistry for CD34 and the correlation with CEUS TIC parameters was investigated. Results In CEUS quantitative parameters, PI, TPH, TP and DS had statistical significance in IPB and BUC (all P<0.05). MVD of BUC was obviously higher than that of IPB (P<0.05); TPH and DS both correlated with MVD (r_s=0.74, -0.81, both P<0.05). Conclusion CEUS characteristics has certain clinical value in identification of IPB and BUC. TIC parameters of CEUS can reflect the MVD of IPB and BUC.