卡络磺钠联合西咪替丁治疗上消化道出血的疗效观察

目的观察卡络磺钠联合西咪替丁治疗上消化道出血的临床疗效。方法选取2015年1月—2016年3月于湖北医药学院附属东风医院接受治疗的上消化道出血患者78例,随机分为对照组和治疗组,每组各39例。对照组给予西咪替丁注射液,取2 m L用5%葡萄糖注射液稀释后静脉推注,根据患者出血情况而定,最多每6小时静推1次。治疗组在对照组的治疗基础上加用注射用卡络磺钠,60~80 mg加入5%葡萄糖液稀释后静脉滴注,1次/d。两组治疗疗程均为72 h。观察两组的临床疗效和止血效果,比较两组治疗前后血小板的变化情况。结果治疗后,对照组和治疗组的临床总有效率分别为82.05%、94.87%;两组止血总有效率分别为89.74%、97.44%,两组比较差异有统计学意义(P0.05)。治疗组的平均止血时间短于对照组,两组比较差异有统计学意义(P0.05)。治疗后,治疗组患者血小板水平明显升高,高于对照组,两组比较差异有统计学意义(P0.05)。结论卡络磺钠联合西咪替丁治疗上消化道出血具有较好的临床疗效,止血效果较好,具有一定的临床推广应用价值。

Clinical observation of carbazochrome sodium sulfonate combined with cimitidine in treatment of upper gastrointestinal hemorrhage

Objective To observe the clinical efficacy of carbazochrome sodium sulfonate combined with cimitidine in treatment of upper gastrointestinal hemorrhage. Methods Patients (78 cases) with upper gastrointestinal hemorrhage in Dongfeng Hospital Affiliated to Hubei University of Medicine from January 2015 to March 2016 were randomly divided into control and treatment groups, and each group had 39 cases. Patients in the control group were iv administered with Cimitidine Injcetion, 2 mL was diluted with 5% glucose injection. According to the hemorrhage, the patients were iv injected once every 6 h at most. Patients in the treatment group were iv administered with Carbazochrome Sodium Sulfonate for injection on the basis of the control group, and 60-80 mg was added into 5% glucose injection, once daily. Patients in two groups were treated for 72 h. After treatment, the clinical efficacy and hemostatic effect were evaluated, the changes of platelet in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.05% and 94.87%, respectively, hemostatic effects in two groups were 89.74% and 97.44%, and there were differences between two groups (P<0.05). The average hemostasis time in the treatment group was shorter than that in the control group, and there were differences between two groups (P<0.05). After treatment, the platelet level in the treatment group was increased significantly, and the platelet level in the treatment group was higher than that in the control group, and there were differences between two groups (P<0.05). Conclusion Carbazochrome sodium sulfonate combined with cimitidine has clinical curative effect in treatment of upper gastrointestinal hemorrhage, and hemostatic effect is better, which has a certain clinical application value.