| 敌百虫暴露对孕鼠脏器及胎鼠DNA和生长发育的影响 |
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| 引用本文： | 丁瑜,周淑芳,沈莉,高宇,施蓉,周义军,田英.敌百虫暴露对孕鼠脏器及胎鼠DNA和生长发育的影响[J].上海交通大学学报(医学版),2009,29(3). |
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| 作者姓名： | 丁瑜 周淑芳 沈莉 高宇 施蓉 周义军 田英 |
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| 作者单位： | 上海交通大学,公共卫生学院,上海,200025
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| 基金项目： | 国家自然科学基金，上海市教育委员会资助项目，上海市科委研发基地项目，上海市卫生局基金 |
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| 摘 要： | 目的 研究低剂量有机磷农药敌百虫暴露对孕鼠脏器及胎鼠DNA和生长发育的影响.方法 雌性ICR小鼠,随机分为空白对照组、10 mg/kg敌百虫染毒组和50 mg/kg敌百虫染毒组.每组至少10只孕鼠,孕前和孕期以饮水方式染毒共30 d,于孕第17天断髓处死,比较孕鼠染毒前后体质量和脏器系数;观察胎鼠生长发育情况,并行单细胞凝胶电泳实验检测胸腺DNA损伤(DNA百分含量、尾长、尾矩、Olive尾矩、细胞拖尾率).结果 染毒组孕鼠除肝脏脏器系数较对照组显著降低外(P<0.01),体质量及胸腺和卵巢等脏器系数与对照组比较差异均无统计学意义(P>0.05).50 mg/kg染毒组胎鼠体质量较对照组明显降低(P<0.05);而染毒组的活胎、死胎及畸形发生率等与对照组比较差异均无统计学意义(P>0.05).染毒组胎鼠胸腺DNA损伤各项指标均较对照组严重(P<0.05或P<0.01).结论 经口敌百虫暴露(10、50 mg/kg),在未对孕鼠产生明显毒性的情况下,可引起胎鼠生长发育延缓和DNA遗传学损伤.
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| 关 键 词： | 敌百虫 生长发育 损伤 胚胎 孕鼠 |
Effects of trichlorfon exposure on maternal organ,fetal DNA and development in mice |
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| DING Yu,ZHOU Shu-fang,SHEN Li,GAO Yu,SHI Rong,ZHOU Yi-jun,TIAN Ying.Effects of trichlorfon exposure on maternal organ,fetal DNA and development in mice[J].Journal of Shanghai Jiaotong University:Medical Science,2009,29(3). |
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| Authors: | DING Yu ZHOU Shu-fang SHEN Li GAO Yu SHI Rong ZHOU Yi-jun TIAN Ying |
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| Institution: | School of Public Health;Shanghai Jiaotong University;Shanghai 200025;China |
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| Abstract: | Objective To investigate the effects of low dose trichlorfon exposure on the maternal organ,fetal DNA and development in mice. Methods Pregnant ICR mice were randomly divided into control group,10mg/kg trichlorfon group and 50mg/kg trichlorfon group,and were administrated 0,10 and 50mg/kg trichlorfon,respectively by water consumption for 30d. All mice were sacrificed on gestation d 17,and body weight and organ coefficient of pregnant mice were compared among groups before and after exposure to trichlorfon. ... |
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| Keywords: | DNA |
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