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| 高效液相色谱法测定奥美拉唑血药浓度及其药代动力学 | |
| 引用本文： | 张静,邵志高,王宇环,杨辉.高效液相色谱法测定奥美拉唑血药浓度及其药代动力学[J].药学与临床研究,2001,9(4):8-10. |
| 作者姓名： | 张静 邵志高 王宇环 杨辉 |
| 作者单位： | 1. 南京医科大学第一附属医院,南京,210029 2. 江苏省中医药研究所,南京,210028 3. 连云港海州医院,连云港,222000 |
| 摘 要： | 建立了用反相高效液相色谱法测定血浆中奥美拉唑含量的分析方法.该分法采用液相提取预处理血样,在25～2000 ng/ml的浓度范围,线性关系良好,最低检测浓度4 ng/ml,奥美拉唑的相对回收率(98.07±5.21)%,日内变异＜3.0%,日间变异＜8.5%.并且,应用本法对正常人静脉推注奥美拉唑进行了药代动力学研究. |
| 关 键 词： | 奥美拉唑 高效液相色谱法 药代动力学 血浆 含量测定 |
| 修稿时间： | 2001年6月29日 |
Determination of Omeprazole in Plasma and Its Pharmacokinetics by HPLC |
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| Zhang Jing,Shao Zhigao,Wang Yuhuan,Yang Hui The No. Affiliated hosptal of Nanjing Medical University.Determination of Omeprazole in Plasma and Its Pharmacokinetics by HPLC[J].Pharmacertical and Clinical Research,2001,9(4):8-10. | |
| Authors: | Zhang Jing Shao Zhigao Wang Yuhuan Yang Hui The No Affiliated hosptal of Nanjing Medical University |
| Institution: | Nanjing 210029 |
| Abstract: | A reversed-phase HPLC method for quantitative determination of orneprazole in plasma was established. The blood plasma sample detection was pretreated by liquid-liquid extraction. Calibration curves in the range 25-2000 ng/ml for omeprazole were linear. The lower limited concentration was 4 ng/ml. The recovery rate of omeprazole was (98. 07 5. 21)%. The intraday and interday cofficients of variation were <3% and <8. 5% respectively. The pharmacokinetic characteristics of omeprazole in normal subjects after a single iv administered were investigated by the method. |
| Keywords: | Omeprazole HPLC Pharmacokinetics Blood plasma Determination of content |
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