Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender |
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| Authors: | Thiago M C Pereira Breno V Nogueira Leandro C F Lima Marcella L Porto Jose A Arruda Elisardo C Vasquez Silvana S Meyrelles |
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| Institution: | (1) Laboratory of Transgenes and Cardiovascular Control, Physiological Sciences Graduate Program, Health Sciences Center, Federal University of Espírito Santo, Av. Marechal Campos 1468, ES 29043-900 Vitoria, Brazil;(2) Research Center, Emescam College of Health Sciences, Vitoria, ES, Brazil |
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| Abstract: | Background Although advanced age is considered a risk factor for several diseases, the impact of gender on age-associated cardiovascular
diseases, such as atherosclerotic processes and valvular diseases, remains not completely clarified. The present study was
designed to assess aortic valve morphology and function and vascular damage in elderly using the apolipoprotein E knockout
(ApoE KO) mouse. Our hypothesis was that advanced age-related cardiovascular changes are aggravated in atherosclerotic male
mice. |
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