严格血糖控制对体外循环术后高敏C反应蛋白的影响

目的观察体外循环术中、术后严格血糖控制对非糖尿病患者体外循环术后高敏C反应蛋白的影响。方法 64例患者随机分为两组,A组作为强化治疗组从手术开始即行强化胰岛素治疗,将血糖严格控制于3.9～8.3 mmol/L。B组作为对照组将血糖控制在11.1 mmol/L以下。体外循环术后检测血液高敏C反应蛋白浓度。结果两组病例的一般情况比较差异无统计学意义。A组高敏C反应蛋白浓度较B组明显降低,差异有统计学意义(P0.05)。结论体外循环术中、术后应用胰岛素严格控制血糖可降低患者高敏C反应蛋白水平,减轻炎症反应。

Effects of strict glycemic control on high-sensitive C reactive protein in patients undergoing cardiac surgery under cardiacpulmonary bypass

Objective To observe the effects of strict glycemic control on high-sensitive C reactive protein in patients undergoing cardiac surgery under cardiacpulmonary bypass.Methods The non-diabetic patients undergoing cardiac surgery under cardiacpulmonary bypass in our department were selected and assigned to intensive therapy group(group A, n=32) and received strict glycemic control after the initiation of surgery. And those who undergoing cardiac surgery but without strict glycemic control were assigned to routine therapy group (group B, n=32) as controls. The blood glucose in group A was maintained at 3.9-8.3 mmol/L, whereas the glucose in group B was at below 11.1 mmol/L. The concentration of high-sensitive C reactive protein were measured after the surgery. Results There were no significant difference in general data between the two groups. The concentration of high-sensitive C reactive protein in group A was decreased, and there was significant difference between the two groups (P<0.05).Conclusion The change of HsCRP shows that strict glycemic control may mitigate inflammatory response.