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| AN EPIDEMIOLOGICAL EVIDENCE OF MULTISTAGE PROCESS OF STOMACH CANCER | |
| 作者姓名： | 游伟程 李吉友 罗云生 全懋林 韩中祥 徐光炜 |
| 作者单位： | You Weicheng; William J.Blotz;Li Jiyou; Robert W. Kneller;Chang Yunsheng;Jin Maolin; Han Zhongxiang;Joseph F.Fraumeni Jr.;Xu Guangwei;(Beijing Institute for Cancer Research，Beijing，100034 China (National Cancer Institute，Bethesda |
| 摘 要： | ＡＮＥＰＩＤＥＭＩＯＬＯＧＩＣＡＬＥＶＩＤＥＮＣＥＯＦＭＵＬＴＩＳＴＡＧＥＰＲＯＣＥＳＳＯＦＳＴＯＭＡＣＨＣＡＮＣＥＲＹｏｕＷｅｉｃｈｅｎｇ；游伟程；ＷｉｌｌｉａｍＪ．Ｂｌｏｔｚ；ＬｉＪｉｙｏｕ；李吉友ＲｏｂｅｒｔＷ．Ｋｎｅｌｌｅｒ；ＣｈａｎｇＹｕｎ... |
An epidemiological evidence of multistage process of stomach cancer |
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| Weicheng You,William J. Blot,Jiyou Li,Robert W. Kneller,Yunsheng Chang,Maolin Jin,Zhongxiang Han,Joseph F. Fraumeni,Guangwei Xu.AN EPIDEMIOLOGICAL EVIDENCE OF MULTISTAGE PROCESS OF STOMACH CANCER[J].Chinese Journal of Cancer Research,1994,6(2):113-118. | |
| Authors: | Weicheng You William J Blot Jiyou Li Robert W Kneller Yunsheng Chang Maolin Jin Zhongxiang Han Joseph F Fraumeni Guangwei Xu |
| Institution: | 1. Beijing Institute for Cancer Research, 100034, Beijing, China 2. National Cancer Institute, 20892, Bethesda, MD, USA 3. Weifang Medical Institute, 261041, Shandong, China 4. Linqu Public Health Bureau, 252600, Linqu, Shandong, China |
| Abstract: | An endoscopic screening examination was conducted in Linqu county, Shandong Province of China, an area with one of the highest rates for stomach cancer (SC) in the world. A total of 3, 433 residents aged 35 64 were enrolled in this survey.Less than 3% of the subjects had normal or superficisl gastritis(SG), 44. 8% had chronic atrophic gastritis(CAG),33.0% had intestinal metaplasia (IM)and 20. 1% had dysplasia (DYS) as the meet advanced gastric lesions in this population. The transition rates from normal to advanced lesions and SC were calculated in overall and different anatomic locations of the stomach. The transition rates were 98. 3% from SG to CAG, 55.1% from CAG to IM, 38. 3% from IM to DYS and 2. 0% from DYS to SC. Tbe transition rates were significantly higher in the angulus and lesser curvature of antrum than other sites, particularly in the sites of the body.Evidences from this study showed that SC may undergo 3050 years' latent period and involves a multistage process.The probability of transition from normal mucosa to SC is dependept on the transition rate of each intermdiate stage of precancerous lesions. |
| Keywords: | Stomach cancer Epidemiology Precancerous lesion multistage |
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