Pamidronate reduces skeletal events but does not improve progression-free survival in early-stage untreated myeloma: results of a randomized trial |
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Authors: | Musto Pellegrino Falcone Antonietta Sanpaolo Grazia Bodenizza Carlo Cascavilla Nicola Melillo Lorella Scalzulli Potito Rosario Dell'Olio Matteo La Sala Antonio Mantuano Saverio Nobile Michele Carella Angelo Michele |
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Affiliation: | Unit of Hematology and Stem Cell Transplantation, IRCCS Casa Sollievo della Sofferenza Hospital, 71013, S. Giovanni Rotondo, Italy. p.musto@tin.it |
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Abstract: | Ninety patients with untreated, stage I-II A myeloma, were randomised to receive or not monthly infusions of pamidronate (PMD) for 1 year, without additional therapies. Follow-up ranged from 36 to 72 months (median 51 months). Three years after the start of the treatment, the disease had progressed in 25% of PMD treated patients and in 26.8% of controls (p n.s). Median time-to-progression was 16 and 17.4 months, respectively (p n.s). Among the 21 patients who required chemo-radiotherapy, skeletal events (osteolytic lesions, pathological fractures and/or hypercalcemia) developed in 9/11 (81.8%) controls and in 4/10 (40%) of treated patients (p < 0.01). "Prophylactic" administration of PMD may decrease the development of skeletal events, but does not reduce the rate and the time of disease progression in early-stage myeloma. |
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