| 前列腺素E_1对血小板功能的影响和临床应用研究 |
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| 引用本文： | 任艺虹,李天德,陈燕,耿现仓. 前列腺素E_1对血小板功能的影响和临床应用研究[J]. 中国药理学通报, 1998, 0(Z1) |
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| 作者姓名： | 任艺虹 李天德 陈燕 耿现仓 |
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| 作者单位： | 中国人民解放军总医院心内科 北京100853(任艺虹，李天德)，广东省湛江市422医院心内科 湛江524000(陈燕)，河南省安阳市三医院心内科 安阳455000(耿现仓) |
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| 摘 要： | 源于二高-γ-亚麻油脂酸,由磷脂酶A_2活化限速的体内强大内源性扩血管物质前列腺素E_1（PGE_1）的扩血管作用和抑制血小板活性作用仅次于前列环素,并与前列环素存在部分共同受体,主要在肺内产生、肺内代谢。目前发现外源性PGE_1可抑制疾病状态下过度活化的血小板活性,如某些心血管疾病、肾脏疾病、糖尿病都伴有不同特点的血小板活性增加及血管内皮或肾系膜细胞的异常,并有内源性扩血管前列腺素生成减少或效应减低,因而补充外源性前列腺素E_1可能有益。
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| 关 键 词： | 前列腺素E_1 血小板 前列环素 心血管疾病 肾脏疾病 |
Effects on platelet and clinical application of prostaglandin E_1 |
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| REN Yi-Hong,CHEN Yan,GEN Xian-Cang,LI Tian-De. Effects on platelet and clinical application of prostaglandin E_1[J]. Chinese Pharmacological Bulletin, 1998, 0(Z1) |
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| Authors: | REN Yi-Hong CHEN Yan GEN Xian-Cang LI Tian-De |
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| Abstract: | Prostaglandin E1 ( PGE1) , derived from D-HLA and controlled by phospholipidase A2, is a kind of strong endogeneous vasodilator and platelet inhibitor. Its effects on vasculars and platelets are just inferior to prostacyclin only, which is the strongest physiological vasodilator and platelet inhibitor, and the common receptors exits.Now it is found that exogeneous PGE1 can central some kinds of paletet supra-activation in illnesses such as cardiovascular disease, renal disease and diabetes mellitus. So PGE1 may be benificial to those patients. |
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| Keywords: | prostaglandin E1 platelet prosta- cyclin cardiovascular disease renal disease |
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