Clinical profile and outcome of acute respiratory failure |
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Authors: | Karande Sunil Murkey Rajneesh Ahuja Sanjeev Kulkarni Madhuri |
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Institution: | (1) Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India;(2) Flat 24 Joothica 5th Floor, Opposite Grant Road Post Office, 22A Naushir Bharucha Road, 400 007 Mumbai |
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Abstract: | Objective : To examine the etiological factors, clinical features, treatment modalities and outcome of acute respiratory failure in
children.Methods : This hospital-based prospective observational study was conducted over 15 months. Fifty children with acute respiratory
failure, diagnosed by serial arterial blood gas analysis, were consecutively enrolled. Ventilation therapy was initiated when
the FiO2 requirement went above 0.6.Results : Pulmonary diseases accounted for majority (68%) of cases, followed by nervous system (12%); and cardiovascular and skeletal
muscle system diseases (10%, each). Bronchopneumonia was the commonest cause of acute respiratory failure (11 cases). The
majority of cases were in the age group 1 month to < 1 year (26 cases). The commonest signs were altered depth and pattern
of respiration (100%), chest wall retractions (88%), flaring of alae nasae (88%), tachypnea (84%), tachycardia (82%), and
irritability (64%). Cyanosis was noticed in only 26 (52%) cases. Thirty-six (72%) children required ventilation therapy. The
overall mortality was 58%. The mortality was high (55.9% to 66.7%), irrespective of the primary system involved. Significantly
higher mortality was associated with co-existent malnutrition (p<0.001), Type I failure (p=0.039) and ventilation therapy
(p<0.0001).Conclusion : Acute respiratory failure has varied etiology and clinical manifestations, and a high mortality. Its outcome is independent
of age of the child and the primary system involved. Malnutrition and Type I failure are factors associated with a poor outcome. |
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Keywords: | Acute respiratory failure Arterial blood gas analysis Child Developing countries India |
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