隐丹参酮固体分散体的制备及性质研究

目的制备隐丹参酮固体分散体,提高隐丹参酮的溶出度。方法采用溶剂蒸发法制备隐丹参酮-PVP固体分散体,熔融法制备隐丹参酮-PEG固体分散体,利用体外溶出度、差热分析、显微观察研究固体分散体的性质及其对溶出度的影响。结果PVP及PEG固体分散体在45min的溶出度分别达到原料药的9.7倍和7.5倍,固体分散体的DTA曲线中隐丹参酮的特征熔融峰消失。结论两种固体分散体均能显著提高隐丹参酮的溶出度,而PVP固体分散体比PEG固体分散体具有更高的溶出度。

Preparation of cryptotanshinone solid dispersion and its properties

Objective To prepare cryptotanshinone solid dispersion and improve the dissolution of cryptotanshinone. Methods Cryptotanshinone-PVP solid dispersion was made by solvent evaporation method and cryptotanshinone-PEG solid dispersion was made by melting method. Properties of solid dispersion and its effects on dissolution were studied by in vitro dissolution test, DTA, and microscope. Results Solid dispersion dissolutions of PVP and PEG at 45 min were 9.7 and 7.5 times as much as material drug, respectively. Characteristic melting peak of cryptotanshinone in DTA curve of solid dispersion disappeared. Conclusion Dissolution of cryptotanshinone is improved remarkably in two kinds of solid dispersion. Furthermore, dissolution of PVP solid dispersion is higher than that of PEG solid dispersion.