唐山煤矿工人幽门螺杆菌感染的影响因素调查

目的 了解煤矿工人幽门螺杆菌(Hp)感染情况及其影响因素。方法 采用多阶段分层随机整群抽样方法选取425名煤矿工人,进行问卷调查。同时行胃镜检查,采取胃黏膜标本用于菌培养和病理诊断;Hp感染的检测方法采用细菌培养法和ELISA法;全部调查资料采用X~2分析和分层分析。结果 煤矿工人Hp总的感染率为69.9％,井下工人的Hp感染率比井上工人的高,差异有显著性(P=0.004);大兴矿、鲍店矿、唐山矿工人Hp的感染率差别无显著性(P>0.05)。影响煤矿工人Hp感染的主要因素有年龄、未成年时月人均经济收入、未成年时住房形式、现家庭人口数等社会经济因素,个人嗜好中的饮酒状况。影响井下工人Hp感染还有家庭进餐形式。结论 井下工人Hp感染率比井上工人的高;影响因素有社会经济因素、个人嗜好、家庭进餐形式。

Study on the determinants of Helicobacter pylori infection among coal miners

Objectivc To study the prevalence and determinants of Helicbacter plyori (H.pylori) infection among coal miners and to seek for competent preventive measures. Methods 425 coalminers from three coal mines, Tangshan, Daxing, and baodian were chosen under stratified random clustersampling. Face to face interview was conducted to fill the unified questionnaires by trained interviewers.306 subjects underwent gastroenduoscopy to detect the situation of the gastroenduedenal diseases, accordingto the Sydney System of diagnosis. Mucosa biopsies were also undertaken according to the regulated locationfor culture of H. pylori and for pathological examination. Blood samples were obtained to detect the anti-HpU-IgG by enzyme-linked immunosorbent assay (ELISA). H. pylori infection was determined throughculture and ELISA but confirmed under the standards set at the National Congress on GastroduodenalDiseases in 1999. Results Among 425 eligible coal miners being tested, 297 (69.9%) were H. pyloripositive and the rate for those working underground(74. 0%) was higher than that of those working onground(P=0.004). No difference was found among coal miners between the three mines (P>0.05).Age,living conditions in childhood, number of current family members, the amount of alcohol intake andways of eating at home were strongly associated with the status of H. pylori infection. ConclusionsDifference of H. pylori infection prevalences between the underground and the abaveground coal miners wasnoticed Determinants that influencing the H. pylori infection would include socioeconomic factors,individual habits and ways of eating at home.