Gastric Mucosa Epithelial Cell Kinetics Are Differentiated by Anatomic Site and Helicobacter PyloriInfection |
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Authors: | Panagiota Kitsanta MD Konstantinos Triantafyllou MD PhD Maria Chatziargyriou MD Charalambos Barbatzas MD PhD Spiros D. Ladas MD PhD |
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Affiliation: | (1) Histopathology Department, Sheffield Teaching Hospitals, Sheffield, United Kingdom;(2) Hepato-Gastroenterology Unit, Second Department of Internal Medicine, Medical School, Attikon University General Hospital, Athens University, Athens;(3) Gastroenterology Unit, Sismanogleion Hospital, Athens, Greece;(4) Hepato-Gastroenterology Unit, 2nd Department of Internal Medicine, Attikon University General Hospital, 23 Sisini Street, 11528 Athens, Greece |
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Abstract: | Changes in epithelial cell turnover related to Helicobacter pylori infection may contribute to gastric cancer development. The response of different anatomic sites of the gastric mucosa to H. pylori is not known. We studied apoptosis and cell proliferation at the grater and lesser curvature of the antrum and corpus, the fundus, and the cardia from 9 H. pylori gastritis patients and 11 H. pylori-negative controls with normal histology. Proliferation was highest at the major curve of the antrum and lowest at the fundus, and apoptosis was highest at the cardia and lowest at the major curve of the antrum in both H. pylori gastritis and normal mucosa. Proliferation was significantly higher at all anatomic sites, while apoptosis was significantly lower only at the major and lesser curve of the corpus in H. pylori gastritis compared with normal controls. Our data suggest that gastric mucosa epithelial cell kinetics is differentiated by the anatomic site and H. pylori infection. |
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Keywords: | gastric mucosa apoptosis cell proliferation gastric cancer Helicobacter pylori |
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