Human pituitary somatotroph adenoma and prolactinoma: An ultrastructural and immunoelectron microscopical study |
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Authors: | Zhou Xiao-jun Zhang Tai-he Yu Yi-qiang Wang Fu-an |
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Institution: | (1) Department of Ultrastructural Pathology, Jinling Hospital, Nanjing |
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Abstract: | Summary 17 cases of pituitary somatotroph adenoma and 38 cases of prolactinoma were studied with electron microscopy and immunoelectron
microscopy using protein A-gold complex. 4 adenomas were shown by immunoelectron microscopy to contain simultaneously growth
hormone (GH)-producing and pcolactin (PRL)-producing cells. 6 cases were classified as densely granulated GH adenomas and
11 as sparsely granulated variant, wheceas only 3 adenomas out of 38 prolactinomas were identified as densely granulated adenomas.
The present study showed that not all cells with fibrous bodies possessed secretory granules positive for GH, and in some
cells with fibrous bodies. PRL-producing granules were also detected. Misplaced exocytosis was found frequently in the sparsely
granulated prolactinomas. From these findings it may be suggested that fibrous bodies are not a morphological feature characteristic
of pituitary somatotroph adenomas. |
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Keywords: | pituitary adenomas growth hormone prolactin fibrous bodies immunoelectron microscopy |
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