| 脂质体对羟喜树碱内酯环的保护 |
| |
| 引用本文： | 周卫,丁逸梅,王丽杰. 脂质体对羟喜树碱内酯环的保护[J]. 中国药学杂志, 2005, 40(9): 688-690 |
| |
| 作者姓名： | 周卫 丁逸梅 王丽杰 |
| |
| 作者单位： | 1. 江苏省药物研究所,江苏,南京,210009
2. 锦州医学院,辽宁,锦州,121001 |
| |
| 基金项目： | 江苏省人事厅六大人才高峰项目 |
| |
| 摘 要： | 目的考察脂质体对羟喜树碱的结构中α-羟基内酯环的保护作用。方法采用HPLC测定模拟生理pH下(pH7.4磷酸盐缓冲液,37℃)羟喜树碱脂质体中羟喜树碱以内酯环结构存在的含量。色谱条件为:色谱柱为C18柱(5μm,4.6 mm×250 mm),流动相为甲醇-水(60:40),检测波长为266 nm。结果在模拟生理pH下24 h受脂质体包裹的羟喜树碱的闭环率仍大于90%。结论说明脂质体对羟喜树碱结构具有较好的保护作用,能有效地保护羟喜树碱的α-羟基内酯环。
|
| 关 键 词： | 羟喜树碱 脂质体 内酯环 |
| 文章编号： | 1001-2494(2005)09-0688-03 |
| 收稿时间： | 2004-08-12; |
Effect of liposomes on the lactone moiety of hydroxycamptothecin |
| |
| ZHOU Wei,DING Yi-mei,WANG Li-jie. Effect of liposomes on the lactone moiety of hydroxycamptothecin[J]. Chinese Pharmaceutical Journal, 2005, 40(9): 688-690 |
| |
| Authors: | ZHOU Wei DING Yi-mei WANG Li-jie |
| |
| Affiliation: | 1.Jiangsu Institute of Materia Medica， Nanjing 210009， China；2.Jinzhou Medical College，Jinzhou 121001， China |
| |
| Abstract: | OBJECTIVE To investigate the potential of liposome for stabilizing lactone ring of hydroxycampothecin(HCPT) . METHODS HPLC method was used to determine lactone form of HCPT in liposomes in stimulated physiological environment. HPLC method was performed on a C18 column (5μm,4.6mm×250 mm) with the mobile phase of methanol-water(60:40). HCPT was determined at 266 nm. RESULTS More than 90% HCPT in liposomes remained its lactone form in stimulated physiological environment for 24 h. CONCLUSION Liposomes may be a useful dosage form to stabilize HCPT. |
| |
| Keywords: | hydroxycamptothecin liposome lactone ring |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中国药学杂志》浏览原始摘要信息 |
|
点击此处可从《中国药学杂志》下载全文 |
