胰岛素受体G6244A基因多态性与江苏东台农村地区原发性高血压的关系

目的探讨胰岛素受体G6244A基因多态性与江苏东台农村地区人群原发性高血压（EH）发病风险的相关性。方法选择东台农村地区190例EH患者（EH组）和94例血压正常者（对照组）作为研究对象。用基因芯片法检测胰岛素受体基因G6244A位点的基因型，比较EH组及对照组基因型分布及等住基因频率的差异。结果两组受检者身高、腰围、臀围、收缩压和舒张压间差异有统计学意义（P〈0．05）；其余指标间差异无统计学意义（P〉0．05）；EH组和对照组胰岛素受体G6244A位点的基因型分布及其等位基因频率间差异均无统计学意义（P〉0．05）。结论胰岛素受体基因G6244A位点多态性与江苏东台农村地区高血压发病风险尚未发现存在相关性，需在今后的研究中进一步证实。

Association of Insulin Receptor G6244A Gene Polymorphism with the Risk of Essential Hypertension in Dongtai of Jiangsu Province

Objective To investigate the correlation of insulin receptor gene G6244A polymorphism with the risk of essential hypertension(EH) in rural population in Dongtai of Jiangsu Province. Methods A total of 190 EH patients (EH group) and 94 sex-and-age-matched controls (control group) was enrolled as subjects. Genetype of insulin receptor gene G6244A was analyzed by gene chip technology. The differences in genetype and allele frequency distribution between the two groups were compared. Results The differences in height, waist line and hip line, and systolic and diastolic pressures between the two groups were of statistically significance (P<0.05), but in the rest indices were of no statistically significance (P>0.05). And the genetype and allele frequency distribution of insulin receptor gene G6244A showed no significant between EH and control groups (all P>0.05). Conclusion No correlation of insulin receptor gene G6244A polymorphism with pathogenic risk of essential hypertension is found in rural population in Dongtai of Jiangsu Province. The further studies are wanted to validate our findings.