460 Cases of Radiotherapy for Primary Massive Liver Cancer

Objective To summarize the improvement of technological by radiotherapy with moving split fields radiation （MSFR） of the whole liver and diminution field technology and split course and to explore the significance by radiotherapy for primary massive Liver Cancer （PLC）. Methods 460 patients with PLC underwent in our hospital between 1987 and 2001 were carried out for retrospective analysis. There were 386 male and 74 female cases of these patients, and the average age was 46.2 years, The tumor size of 245 patients is 10-15 cm. The others is 15-21 cm. There were three groups defined by the irradiation doses： （1） 260 patients treated with moving split fields radiation （MSFR） of the whole liver twice, mTD 16-19 Gy. （2） 127 patients treated with MSFR of the whole liver 3-4 times, mTD 24-35 Gy. （3） 73 patients treated with moving split radiation of the whole liver and diminution field technology and split course, mTD 50-60Gy. Results （1） The tumor size of group 1 had been reduced 10-20%, and the painless rate （Clinical Benefit Response CBR） was 81.5% （2121260）. The half-year and 1-year survival rate was 62.8% and 19.8%, with median survival duration of 8 months. （2） The tumor size of group 2 had been reduced 20-30%, and the painless rate （CBR） was 90.5% （1151127）, the half-year and 1-year survival rates were 82.5% and 28.5%, with a median survival duration of 11 months. （3） The tumor size of group 3 had been obviously reduced more than 40-50%, CBR was 100%. 1-, 2-, 3-, 4- and 5-year survival rate were 95.8%, 69.8%, 47,9%, 27.3% and 10.9%. 10 patients of them, whose median tumor diameter reduced from 14cm to 7cm, accepted operation after radiotherapy, and the 5-year and 10-year survival rate were 40% and 30%, with the longest survival duration of more than 18 years. Conclusion It has been proved that technological radiotherapy about the MSPR of the whole liver, diminution field technology and split course, could he safe and effective selection with the treatment of PLC. There are more fields of indication than usual. It is technologic improvement among the design of radiate field, boost of the posology in target area and the radioactive tolerance dose. It is suggestible for applying and exploring in further places.

460 Cases of Radiotherapy for Primary Massive Liver Cancer