| 一效膏促进小鼠皮肤溃疡愈合的实验研究 |
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| 引用本文： | 宋珊珊,李大勇,吕延伟. 一效膏促进小鼠皮肤溃疡愈合的实验研究[J]. 辽宁中医药大学学报, 2011, 0(9): 40-42 |
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| 作者姓名： | 宋珊珊 李大勇 吕延伟 |
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| 作者单位： | 辽宁中医药大学第一临床学院;辽宁中医药大学附属医院血管外科; |
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| 基金项目： | “十一五”国家科技支撑计划项目(2008BAI53B012) |
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| 摘 要： | 目的:通过观察一效膏对小鼠皮肤溃疡动物模型的疗效影响及比较研究,探讨一效膏对皮肤溃疡的治疗机制,为临床上运用一效膏治疗皮肤溃疡提供实验依据。方法:54只清洁级小鼠随机分为实验组、阳性对照组及模型对照组,建立皮肤溃疡模型,对实验组皮损部位外敷一效膏,阳性对照组皮损部位外敷贝复济,模型对照组皮损部位外敷生理盐水。定期肉眼观察溃疡、测量面积并计算收缩率;做常规病理、VEGF、EGFR和CD34免疫组化方法标记观察毛细血管表达情况并进行计算。结果:治疗过程中,脱落小鼠4只,造模后3、7、12天实验组与阳性对照组创面收缩率好于模型对照组(P<0.05);造模后12天常规病理显示3组间有差异,免疫组化VEGF、EGFR和CD34标记显示,实验组和阳性对照组之间无显著差异,但两组均与模型对照组之间有显著差异(P<0.05)。结论:一效膏可促进小鼠皮肤溃疡的愈合,改善皮肤溃疡局部血液循环,促进成纤维细胞增殖和新生毛细血管形成、肉芽组织生长。
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| 关 键 词： | 一效膏 皮肤溃疡 实验研究 |
A Effect Creams Promote Human Skin Ulcer Healing of Experiments |
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| SONG Shan-shan,LI Da-yong,LU Yan-wei. A Effect Creams Promote Human Skin Ulcer Healing of Experiments[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2011, 0(9): 40-42 |
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| Authors: | SONG Shan-shan LI Da-yong LU Yan-wei |
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| Affiliation: | SONG Shan-shan1,LI Da-yong2,LU Yan-wei2(1.Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China,2.The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,China) |
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| Abstract: | Objective:Through the observation of Yixiao ointment of animal models of curative effect,this paper discusses the influence and a comparative study of Yixiao ointment,treatment function and mechanism for clinical use Yixiao ointment to provide the evidence that the treatment of skin ulcers.Method:54 only clean level randomly divided into experimental mice,positive control group and control group,established model skin ulcers model for vitiligo patches on Yixiao ointment,positive effect creams vitiligo patch... |
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| Keywords: | Yixiao ointment skin ulcer experimental study |
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