| 土槐煎剂治疗寻常型银屑病的疗效及其对VEGF的影响 |
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| 引用本文： | 唐春蕾,吕静,史月君.土槐煎剂治疗寻常型银屑病的疗效及其对VEGF的影响[J].辽宁中医药大学学报,2011(9):36-37. |
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| 作者姓名： | 唐春蕾 吕静 史月君 |
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| 作者单位： | 大连市皮肤病医院; |
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| 基金项目： | 美国NIH科研基金项目(AR050629AR9098); 大连市科技局支持项目(2007E21SF205) |
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| 摘 要： | 目的:观察土槐煎剂治疗寻常型银屑病的临床疗效,探讨土槐煎剂治疗寻常型银屑病的作用机制。方法:(1)将180例寻常型银屑病患者随机分为治疗组(90例,土槐煎剂治疗)和对照组(90例,复方青黛丸治疗),治疗4周,记录其疗效和不良反应。(2)采用酶联免疫吸附(ELISA)法检测治疗组患者治疗前后血清中血管内皮生长因子(VEGF)水平,并与正常组比较。结果:(1)治疗组总有效率为66.67%,与对照组比较均有显著差异(χ2=7.33,P<0.05)。(2)两组均无严重不良反应,不良反应发生率比较无显著性差异(χ2=0.97,P>0.05)。(3)土槐煎剂治疗前银屑病患者血清中VEGF质量浓度明显高于正常组(P<0.01);土槐煎剂治疗4周后银屑病患者血清中VEGF质量浓度明显降低,与治疗前比较差异有统计学意义(P<0.01),与正常组相比较差异有统计学意义(P<0.05)。结论:中药土槐煎剂治疗寻常型银屑病安全、高效,能够降低寻常型银屑病患者血清中VEGF质量浓度,抑制血管新生可能是中药土槐煎剂治疗寻常型银屑病的机制之一。
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| 关 键 词： | 土槐煎剂 银屑病 血管内皮生长因子 |
Effects of Tuhuai Apozema and Its Affection on the Serum Levels of VEGF in Patients with Psoriasis Vulgaris |
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| TANG Chun-lei,LU Jing,SHI Yue-jun.Effects of Tuhuai Apozema and Its Affection on the Serum Levels of VEGF in Patients with Psoriasis Vulgaris[J].Journal of Liaoning University of Traditional Chinese Medicine,2011(9):36-37. |
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| Authors: | TANG Chun-lei LU Jing SHI Yue-jun |
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| Institution: | TANG Chun-lei,LU Jing,SHI Yue-jun(Dalian Dermatology Hospital,Dalian 116021,Liaoning,China) |
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| Abstract: | Objective:To observe the clinical efficacy of Tuhuai Apozema in the treatment of psoriasis vulgarism and To investigate the action mechanism of tuhuai Apozema in the treatment psoriasis vulgaris.Methods:(1)180 patients with Psoriasis Vulgaris were divided randomly into two groups-the treatment group(90 cases,treated with Tuhuai Apozema)and the control group(90 cases,treated with indigo naturalis pills compound).The therapeutic effects and the adverse effects were recorded as the courses(4 weeks)completed.(2... |
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| Keywords: | Tuhuai Apozema Psoriasis VEGF(Vascular Endothelial Growth Factor) |
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