3-Epihydroxy lup-20(29)-en-19(28)-olide: partial synthesis,antitopoisomerase activity,and 3D molecular docking |
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| Authors: | Amitava Mandal Ashim Ghosh Shilpi Ghosh Suranjan Shil Asim Kumar Bothra Pranab Ghosh |
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| Institution: | 1.Natural Products and Polymer Chemistry Laboratory, Department of Chemistry,University of North Bengal,Darjeeling,India;2.Department of Biotechnology,University of North Bengal,Darjeeling,India;3.Department of Chemistry,Raiganj University,North Dinajpur,India |
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| Abstract: | A novel method for the partial synthesis of the rare triterpenoid, 3-epihydroxy lup-20(29)-en-19(28)-olide, and 1 from betulinic acid is reported. The binding efficiency, mode of binding for different compounds to the central catalytic domain of topoisomerase IIα, was calculated from a complete 3D molecular docking study on the crystal structure of the enzyme (1bgw, pdb). The compounds 1, 2b, and 2d showed a dose-dependent inhibition of catalytic activity of topoisomerase IIα. |
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